Postdoc (F/m/x) in The Group Mechanisms of

vor 3 Wochen

Ulm, Deutschland Deutsches Zentrum für Neurodegenerative Erkrankungen Vollzeit

**Postdoc (f/m/x) in the group Mechanisms of Propagation**:
**Code: 6031/2023/6**:
The group of Prof. Karin Danzer (DZNE Ulm site) “Mechanisms of Propagation” where this position will be located study the underlying mechanisms in disease propagation and spreading in neurodegenerative diseases with a main focus on Amyothrophic Lateral Sclerosis (ALS) and Parkinson’s disease (PD). Using innovative animal models and patient samples we try to understand how and why protein aggregates are transmitted from cell to cell (e.g. Kiechle et al. Cell Rep. 2019). We will take these analyses to the next level by multiomic approaches combining single cell RNA sequencing as well as epigenetic profiling of neuronal and non-neuronal cells (e.g. Kühlwein et al. Cell Mol Life Sci. 2023). In addition, we analyze transcriptomics within the tissue context or neurodegenerative diseases using spatial transcriptomics techniques. We will explore transmission to non-neuronal cells and try to pinpoint the contribution of peripheral inflammation, generating a comprehensive map of the molecular alterations defining neurodegenerative processes based on animal models as well as human patients. Furthermore, epigenetic profiling of different cell populations in the brain allows us to discover new pathways involved in ALS and PD and to identify new therapeutic targets.

**Your tasks**:
**Requirements**:

- Sequencing methods and interpretation of large-scale sequencing data
- Bioinformatic analyses
- Animal models for neurodegenerative diseases
- Working with primary cells (e.g. PBMCs, neuronal cells)
- In-depth experience with cell culture models for neurodegeneration

**We offer**:

- A well-funded research project at the cutting edge of neurodegeneration research
- Excellent scientific infrastructure and state of the art techniques
- An international environment characterized by a strong focus on science and research
- Working in an international team within a stimulating research environment and very well-equipped laboratories
- A high potential for the individual development of our employees (including targeted personnel development)
- A full-time position, initially temporary limited to 2 years, with possible extension
- Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst - TVöD Bund)

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