Phd in The Field of Transposon-based Gene Therapy

vor 5 Monaten


Leipzig, Deutschland Cell Therapy and Immunology Vollzeit

Its Fraunhofer Institute for Cell Therapy and Immunology IZI researches and develops special problem solutions at the interfaces of medicine, life sciences and engineering.

**What you will do**
- The two doctoral projects are part of a new strategic research project funded by the Fraunhofer-Gesellschaft. This aims at addressing unmet needs in efficacy and safety associated with non-viral therapeutic cell engineering by transposon vectors.
- Your area of responsibility lies in the molecular engineering of novel transposon and transposase components.
- To this end, you will generate variants of transposases and modified versions of transposon vectors and validate these in cultured human cells. You will repeat and optimize the above steps iteratively in order to establish an optimal combination.
- A significant component of the work will be the generation of transposon vector integration site libraries in cultured human cells and annotatation of those insertions by next-generation sequencing and bioinformatics tools.
- You will make genetic modifications to primary immune cells (T cells, NK cells) with the improved vector components in order to evaluate the performance of the system in therapeutically relevant human cells.
- You will communicate your research results in writing within the framework of corresponding publications as well as orally at regular colloquia and at specialist meetings or conferences.

**What you bring to the table**
- You have successfully completed a Master's or Diploma degree in life sciences.
- You have already gained experience in molecular and cell biology as part of your studies and previous career. Ideally, you also have knowledge of bioinformatics; however, this is not a prerequisite.
- You are very confident in oral and written communication in English and enjoy working in an interdisciplinary team.
- Your working style is characterized by curiosity, commitment and initiative and you approach new challenges independently and flexibly.

**What you can expect**
- At the Fraunhofer IZI, creative research freedom meets real added value for society through close links to industry.
- A PhD in a challenging interdisciplinary work environment with access to state-of-the-art research technologies and the opportunity to actively shape your field of work and advance your ideas in national and international scientific collaborations.
- Comprehensive further training opportunities and support services as part of your doctorate - further information on our doctoral program can be found here.
- Flexible working hours and home office options, taking into account your professional and private challenges
- A wide range of support services for balancing family and career (e. g. parent-child office, childcare facility at the institute)
- Good transport links with free car parking and secure bicycle parking spaces, charging stations for electric vehicles and a discounted Germany Job Ticket for local public transport
- Discounted employee prices in the institute’s canteen

Curious to find out more? Click here to get more information on what it's like to work at the Fraunhofer IZI and the benefits we offer our employees.

The position is initially limited to 3 years. The full-time position (39 hours per week) with 65% remuneration offers 35% of the working time for working on your own doctoral project and 65% of the working time for working on the institute's research projects. Employment, remuneration and social benefits are based on the collective agreement for the public sector (TVöD). In addition, Fraunhofer may grant performance
- and success-based variable remuneration components.

Please do not hesitate to contact us if you have any questions about this position:
Prof. Dr. Zoltan Ivics

Fraunhofer Institute for Cell Therapy and Immunology IZI

Requisition Number: 73839 Application Deadline:



  • Leipzig, Deutschland Cell Therapy and Immunology Vollzeit

    Its Fraunhofer Institute for Cell Therapy and Immunology IZI researches and develops special problem solutions at the interfaces of medicine, life sciences and engineering. **What you will do** - Your research will focus on the analysis of efficacy, cytotoxicity and mechanisms of action, both in vitro at the cellular level and in vivo in a mouse model. -...

  • Technical Assistant

    vor 5 Monaten


    Leipzig, Deutschland Cell Therapy and Immunology Vollzeit

    Its Fraunhofer Institute for Cell Therapy and Immunology IZI researches and develops special problem solutions at the interfaces of medicine, life sciences and engineering. One of its main tasks is contract research for biotechnological, pharmaceutical and medical technology companies, clinics, diagnostic laboratories and research institutes. **What you...


  • Leipzig, Deutschland Cell Therapy and Immunology Vollzeit

    **What you will do** For the joint Master Thesis, we aim for the selective functionalization of a carbon nanotube-based biosensor and investigation of the transistor characteristics upon exposure to liquid environments. This includes the optimization of functionalization routes for different probes and the study of surface properties. The device...


  • Leipzig, Deutschland Cell Therapy and Immunology Vollzeit

    The Fraunhofer Institute for Cell Therapy and Immunology IZI researches and develops special problem solutions at the interfaces of medicine, life sciences and engineering. At Fraunhofer IZI, the Bioinformatics Unit is looking for a Master’s student to work on a thesis project at the Leipzig site. The group uses computer-aided methods combined with...


  • Leipzig, Deutschland Max-Planck-Institut für evolutionäre Anthropologie Vollzeit

    **Max-Planck-Institut für evolutionäre Anthropologie** - **Zentrales Bewerbermanagement**: About MPI-EVA The Max Planck Institute for Evolutionary Anthropology unites scientists with various backgrounds (natural sciences and humanities) whose aim is to investigate the history of humankind from an interdisciplinary perspective with the help of comparative...


  • Leipzig, Sachsen, Deutschland Helmholtz-Zentrum für Umweltforschung GmbH - UFZ Vollzeit

    Research Position in Microbiome DynamicsWe are seeking a highly motivated PhD researcher to investigate the metabolic interaction within a microbiome model system, focusing on the production of nucleotides. The project aims to decipher nucleotides' role in the human microbiome model system SIHUMIx.Key Responsibilities:Cultivate the SIHUMIx consortium in...


  • Leipzig, Deutschland Cell Therapy and Immunology Vollzeit

    The Fraunhofer Institute for Cell Therapy and Immunology IZI researches and develops special problem solutions at the interfaces of medicine, life sciences and engineering. For a research group** **at our **Leipzig** site we are looking for an experienced scientist who is motivated to co-lead a dynamic and multidisciplinary team of researchers and provides...

  • Phd Researcher

    vor 2 Monaten


    Leipzig, Deutschland Helmholtz-Zentrum für Umweltforschung UFZ Vollzeit

    Place of work Leipzig - Working time 65% (25.35h / week) - Contract limitations limited contract / 3 years - Salary Remuneration according to the TVöD public-sector up to pay grade 13 including attractive public-sector social security benefits. - Contact **Your contact for any questions you may have about the job**: The UFZ The Helmholtz Centre for...

  • PhD Researcher

    vor 1 Monat


    Leipzig, Deutschland Helmholtz-Zentrum für Umweltforschung GmbH - UFZ Vollzeit

    logo Scientist (m/f/x) - UFZ - logo The UFZ has a strong commitment to diversity and actively supports equal opportunities for all employees regardless of their origin, religion, ideology, disability, age or sexual identity. We look forward to applications from people who are open-minded and enjoy working in diverse teams. Place of work: Leipzig Working...

  • PhD Researcher

    vor 2 Monaten


    Leipzig, Deutschland Helmholtz Centre for Environmental Research Vollzeit

    The UFZ The Helmholtz Centre for Environmental Research (UFZ) with its 1,100 employees has gained an excellent reputation as an international competence centre for environmental sciences. We are part of the largest scientific organisation in Germany, the Helmholtz association. Our mission: Our research seeks to find a balance between social...


  • Leipzig, Sachsen, Deutschland Helmholtz Centre for Environmental Research Vollzeit

    The Helmholtz Centre for Environmental ResearchWe are seeking a PhD Researcher to study the metabolic interaction within a microbiome model system, focusing on the production of nucleotides in the Department of Molecular Toxicology.Your ResponsibilitiesCultivate the SIHUMIx consortium in anaerobic continuous bioreactors and manipulate specific species by the...


  • Leipzig, Deutschland Cell Therapy and Immunology Vollzeit

    The Fraunhofer Institute for Cell Therapy and Immunology IZI researches and develops special problem solutions at the interfaces of medicine, life sciences and engineering. One of the main tasks here is contract research for biotechnological, pharmaceutical and medical technology companies, clinics, diagnostic laboratories as well as research...


  • Leipzig, Deutschland Max-Planck-Institut für evolutionäre Anthropologie Vollzeit

    **Max-Planck-Institut für evolutionäre Anthropologie** - **Zentrales Bewerbermanagement**: About MPI-EVA The Max Planck Institute for Evolutionary Anthropology unites scientists with various backgrounds (natural sciences and humanities) whose aim is to investigate the history of humankind from an interdisciplinary perspective with the help of comparative...

  • Phd Researcher

    vor 1 Monat


    Leipzig, Deutschland Helmholtz-Zentrum für Umweltforschung UFZ Vollzeit

    Place of work Leipzig - Working time 65% (25.35h / week) - Contract limitations limited contract / limited contract / 3 years - Salary Remuneration according to the TVöD public-sector up to pay grade 13 including attractive public-sector social security benefits. - Contact **Your contact for any questions you may have about the job**: Prof. Martin von...

  • PhD Researcher

    vor 4 Wochen


    Leipzig, Deutschland Helmholtz-Zentrum für Umweltforschung (UFZ) Vollzeit

    logoScientist (m/f/x) - UFZ - logoThe UFZ has a strong commitment to diversity and actively supports equal opportunities for all employees regardless of their origin, religion, ideology, disability, age or sexual identity. We look forward to applications from people who are open-minded and enjoy working in diverse teams. Place of work: Leipzig Working...

  • PhD Researcher

    vor 1 Monat


    Leipzig, Deutschland Helmholtz Centre for Environmental Research Vollzeit

    The UFZ The Helmholtz Centre for Environmental Research (UFZ) with its 1,100 employees has gained an excellent reputation as an international competence centre for environmental sciences. We are part of the largest scientific organisation in Germany, the Helmholtz association. Our mission: Our research seeks to find a balance between social...

  • Phd Researcher

    vor 3 Monaten


    Leipzig, Deutschland Helmholtz-Zentrum für Umweltforschung UFZ Vollzeit

    Place of work Leipzig - Working time 65% (25,35 hrs/ week) - Contract limitations limited contract / 3 years - Salary Remuneration according to the TVöD public-sector up to pay grade 13 including attractive public-sector social security benefits. - Contact **Your contact for any questions you may have about the job**: Prof. Dr. Tamara Tal +49 341 6025...


  • Leipzig, Deutschland Max-Planck-Institut für evolutionäre Anthropologie Vollzeit

    **Max-Planck-Institut für evolutionäre Anthropologie** - **Zentrales Bewerbermanagement**: The Max Planck Institute for Evolutionary Anthropology (MPI-EVA) in Leipzig, Germany, is a world-leading research institute investigating one of the most fundamental questions in science: What makes humans human? The institute brings together scientists from a wide...


  • Leipzig, Deutschland CE cideon engineering GmbH & Co. KG Vollzeit

    **cideon engineering - the Enabler.** Rail is the backbone of the mobility of the future. With particular technical challenges such as the implementation of internationally standardised systems to support interoperability or the development of energy-efficient transport modes to reduce emissions and the integration of advanced technologies for...

  • Phd Candidate

    vor 5 Monaten


    Leipzig, Deutschland Helmholtz Zentrum München Vollzeit

    102340 Full time Leipzig We are Helmholtz Munich. In a rapidly changing world, we discover breakthrough solutions for better health. Our research is focused within the areas of metabolic health/diabetes, environmental health, molecular targets and therapies, cell programming and repair, bioengineering, and computational health. We particularly excel in...