Master Thesis/md Thesis: Regulatory Genomic

vor 3 Wochen


Hamburg, Deutschland Leibniz-Institut für Virologie Vollzeit

The Leibniz Institute of Virology (LIV) is an independent research institution for basic biomedical research. As a foundation under civil law and member of the Leibniz Association, the Institute occupies a leading position both nationally and internationally.

We are looking for a highly motivated and team-oriented Master student (f/m/x) in the fields of bioinformatics, informatics, life sciences or similar.

Your tasks

**Project overview**:
Amongst other, we are interested in deciphering how human endogenous retroviruses (HERVs) contribute to immune cell function. HERVs are highly repetitive sequence elements in the human genome that have derived from retroviral infection events during human evolution. These elements comprise around 8% of the human genomic content and have been co-opted to contribute to regulatory gene networks, driving a variety of physiological and pathological states. Our work is focused on how HERVs contribute to lymphocyte and myeloid cell function in particular in the context of HIV-1 infection. The project will involve analysis of multi-modular genomics datasets (RNAseq, ChIPseq, ATACseq) combined with integrative downstream analyses (eg. Differential expression/accessibility, GSEA, WGCNA) (Hamann et al. BMC Medical Genomics, 2023, PMID: 37013607).

**Profile**:

- a highly motivated and team-oriented Master student (M/F/d) in the fields of bioinformatics, informatics, life sciences or similar
- full-time commitment to the project (expected length approx. 7-10 months)
- very good English language skills (oral and written)
- good knowledge on Linux, R based data analysis is a prerequisite, further skills (eg. Python, Biostatistics, basic knowledge of multi-omics data integration) are a plus

What we offer
- an exciting bioinformatics research project in a mixed wet lab/dry lab environment
- close supervision of the project
- an international and thriving research environment at LIV
- possibility to take up HiWi position

The LIV is certified with the Total Equality distinction, and promotes work-life balance and professional equality between all genders. Severely disabled persons will be given preferential consideration if their suitability, qualifications, and professional performance are otherwise equal.

**Contact**:
Leibniz Institute of Virology (LIV) | Martinistraße 52 (N63) | 20251 Hamburg |



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