Research Assistant/ Phd Student

vor 2 Wochen

Halle Saale, Deutschland Martin-Luther-Universität Halle Wittenberg Vollzeit

**External Job Announcement** **Reg.Nr. 7-258/23-D**

Creating Knowledge. Since 1502: Martin Luther University Halle-Wittenberg (MLU) offers a wide range of

largest university in Saxony-Anhalt was created in 1817 when the University of Wittenberg (founded in 1502)

merged with Friedrichs University Halle (founded in 1694). Today the university has 340 professors and 20,000

students. Research at the university focuses on nano and life sciences, the Enlightenment, society and culture._ _

Martin Luther University Halle-Wittenberg, Medical Faculty, Molecular Medicine of Signal Transduction,

offers the third-party funded position of a

Research Assistant/ PhD Student (m-f-d)

starting from 01.02.2024 for the duration of 3 years and in part-time (65%).

Salary will be in accordance with salary class 13 TV-L, pending classification based on individual capacities

and qualifications.

Funded by the German Research Foundation (DFG), this project focuses on the reconstruction of transcrip
- tional networks downstream of the MAPK signaling cascade. MAPK signaling plays a key role in the regula
- tion of cell proliferation, differentiation as well as survival. The constitutive activation of the MAPK signal
- ing cascade by activating mutations of its components, such as EGFR, RAS or BRAF, is one of the main

causes for the development of numerous types of cancer. Despite the clinical relevance of the MAPK signal
- ing cascade, the topology of the transcriptional networks it regulates is still largely unexplored. To investi
- gate these networks in more detail, orthogonal CRISPR screens will be combined with single-cell RNA se
- quencing (scRNA-Seq) and computational methods for modeling transcription networks in close collabora
- tion with the Blüthgen group at Charité Berlin. The aim of the project is to gain new insights into the regu
- lation of transcriptional networks downstream of the MAPK signaling cascade and thereby identify new

therapeutic targets for the treatment of MAPK-related cancers.

**Tasks**:

- Design and cloning of CRISPR sgRNA libraries
- Performance of CROP-Seq experiments in human cancer cell lines
- Bioinformatic analysis of the generated CROP-Seq data
- Scientific processing, presentation and publication of obtained results
- Independent project management
- Participation in national collaborations
- Opportunity for own scientific qualification

**Requirements**:

- Completed scientific university degree in the field of life sciences (Master)
- Extensive experience with molecular cloning techniques
- Experience with lentiviral transduction of human cells
- Experience with genome editing in human cells
- Experience with performing and analyzing scRNA-Seq experiments is an advantage
- Programming skills with R and/or Python are desirable

veröffentlicht am 28.11.2023
- Very good written and spoken English language skills
- Analytical and problem-oriented thinking
- Structured and thorough way of working
- Ability to work in a team
- Ability to cooperate

diverse are particularly encouraged to apply. Applicants with a foreign qualification have to submit the Statement

of Comparability for Foreign Higher Education Qualifications issued by the Central Office for Foreign Education

For further information, please contact Jun.Prof. Michael Böttcher,
- versity Halle-Wittenberg, Medical Faculty, Molecular Medicine of Signal Transduction, Jun.Prof. Michael Bött

only be returned if a prepaid return envelope has been attached.

veröffentlicht am 28.11.2023

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