Research Assistant with The Opportunity for

vor 3 Wochen


Duesseldorf, Deutschland Universität zu Köln Vollzeit

**University of Cologne**

**The University of Cologne is one of the largest and most research-intensive universities in Germany, offering a wide**
**and internationally outstanding profile areas, supported by the administration with its services.**

home) is interested in understanding how axons main
- tain their function during our lifetime and the mecha
- nisms underlying their degeneration in neurological dis
- eases, such as hereditary spastic paraplegia (HSP). HSP is
characterized by the degeneration of axons of cortical
motoneurons that control voluntary movements. In this
project, we aim to investigate the role of metabolic rewir
- ing in the pathogenic cascade of a form of HSP associat
- ed with mitochondrial dysfunction. Ultimately, our goal
is to identify disrupted pathways amenable of therapy.

**YOUR TASKS**
- To investigate pathogenic mechanisms underlying axo
- nal degeneration in hereditary spastic paraplegia, using
mouse models
- To explore genetic and metabolic interventions to halt
the progression of the disease
- To accurately record and analyze your data, according
to good scientific practice

**YOUR PROFILE**
- Master of Science or equivalent in Biology, Genetics or
Neurobiology
- Strong background in neurobiology and/or mitochond
- rial research is essential
- Previous experience in working with mouse models,
and/or neuronal primary cultures will be considered as
a plus
- Curious, motivated and commitment to high-quality
research
- Good communication skills, fluency in English, sense for
teamwork

**WE OFFER YOU**
- Access to core facilities offering state-of-the-art tech
- nologies
- a diverse and fair working environment
- support in reconciling work and family life
- extensive advanced training opportunities
- occupational health management offers
- local transport ticket at a discount for UoC employees

The position is to be filled part-time (65% / 25.89 hours per
week) as soon as possible and is limited to three years. If
the necessary prerequisites required by tariff regulations
as well as the sought-after personal qualifications are met,
the salary will correspond to the pay grade 13 as specified
in the States‘ Tariff Agreement (TVL).

The University of Cologne is committed to equal oppor
- tunities and diversity. Women are especially encouraged to
with the Equal Opportunities Act of North Rhine-Westpha
- lia (Landesgleichstellungsgesetz - LGG NRW). We also ex
special needs or of equal status.

proof of the sought qualifications. The reference number is
Wiss2212-03.

All questions regarding the position should be addressed
- R E:
F W D:
A N T
- **Faculty of Mathematics and Natural Sciences**

**Research assistant with the opportunity for doctorate (f/m/d)**

**Rugarli Lab, Institute for Genetics I CECAD Research Center



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