Phd Student

vor 2 Wochen

Hamburg, Deutschland Leibniz-Gemeinschaft Vollzeit

23.01.2024

**PhD Student (M/F/d) Molecular Parasitology**:
**Bernhard-Nocht-Institut für Tropenmedizin (BNITM), Hamburg**:
The **Molecular Parasitology**group of Dr. Joachim Michael Matz** at the Bernhard Nocht Institute for Tropical Medicine in Hamburg is looking for a highly motivated

**PhD Student (M/F/d)**:
**to study **SNARE proteins in human malaria parasites**

**Description of the project**:
Malaria is a mosquito-borne disease that puts half of the world’s population at risk of infection. It is caused by unicellular _Plasmodium_ parasites, which repeatedly invade and lyse red blood cells in the human bloodstream. Erythrocyte infection is initiated by an extracellular _Plasmodium_ merozoite which attaches to the host cell and then pushes itself into a growing membrane sack. Within this parasitophorous vacuole, the parasite matures and divides until a new generation of invasive daughter merozoites is formed. Invasion, parasite growth and exit from the host cell rely on highly specialized secretory pathways that are utilized by _Plasmodium_ to deliver its proteins to the parasite plasma membrane, to the parasitophorous vacuole and even to the cytosol and surface of the erythrocyte where they modulate the biophysical properties of the host cell. These pathways converge at the parasite surface where cargo-laden vesicles fuse with the _Plasmodium_ plasma membrane. Such fusion events are typically facilitated by SNARE (soluble N-ethylmaleimide-sensitive-factor attachment receptor) proteins. The genome of _Plasmodium falciparum_, the most virulent human malaria parasite, encodes 25 SNARE domain containing proteins and we identified some of them as likely regulators of vesicle fusion at the parasite plasma membrane.

**Your Profile**:

- Diploma/master degree or equivalent in life sciences
- Background in molecular and cellular biology
- Interest in parasitology
- Excellent teamwork and communication skills
- Proficiency in English (written and spoken)
- Ability to work independently and to develop creative work

**Our benefits**:

- An interesting and challenging research project
- Comprehensive training in state-of-the-art genetic and microscopic techniques
- Integration into an open-minded, collaborative, and highly motivated research team
- A structured PhD training program and opportunities for further education and training
- A chance to participate in national and international conferences
- A central and easily accessible location close to the Landungsbrücken
- Flexible and family-friendly working hours
- Subsidy for childcare
- Subsidy for HVV-ProfiTicket as “Deutschlandticket” (Basic)
- Company pension scheme
- Special conditions in selected sports and fitness clubs in Hamburg

Starting date will be as soon as possible. The position is initially limited to 3 years and is remunerated with 65% E 13 TV-AVH according to the rules of the public service under the TV-AVH (collective agreement of the “Arbeitsrechtliche Vereinigung Hamburg“).

As a member of the Diversity Charter, the largest diversity management network in Germany, we are also committed to making diversity an integral part of our institute culture. It is our goal to create a working environment that is free of prejudice.

For further questions please contact Dr. Joachim Michael Matz (joachim.matz(at)bnitm.de).

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