Bioinformatic Postdoc in Cancer Epigenomics
Vor 5 Tagen
**Reference number**:2024-0374**
- Heidelberg
- Full-time
- Cancer Epigenomics
**_“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts - whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting._**
1. Llamazares-Prada M, Schwartz U, Pease DF, Pohl ST, Ackesson D, Li R, Behrendt A, Tamas R, Richter M, Muley T, et al: Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration. bioRxiv 2023.
2. Zhang G, Jurinovic V, Bartels S, Christgen M, Christgen H, Kandt LD, Raap M, Klein J, Katzke A-L, Hofmann W, et al: Development and validation of multivariate predictors of primary endocrine resistance to tamoxifen and aromatase inhibitors in luminal breast cancer reveal drug-specific differences. medRxiv 2023.
3. Gerhauser C, Favero F, Risch T, Simon R, Feuerbach L, Assenov Y, Heckmann D, Sidiropoulos N, Waszak SM, Hübschmann D, et al: Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. Cancer Cell 2018, 34:996-1011 e1018.
4. Weichenhan D, Riedel A, Sollier E, Toprak UH, Hey J, Breuer K, Wierzbinska JA, Touzart A, Lutsik P, Bahr M, et al: Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13). Blood Adv 2024, 8:5100-5111.
5. Scherer M, Singh I, Braun M, Szu-Tu C, Kardorff M, Rühle J, Frömel R, Beneyto-Calabuig S, Raffel S, Rodriguez-Fraticelli A, Velten L: Somatic epimutations enable single - cell lineage tracing in native hematopoiesis across the murine and human lifespan. bioRxiv 2024
6. Kelly K, Scherer M, Braun MM, Lutsik P, Plass C: EpiCHAOS: a metric to quantify epigenomic heterogeneity in single-cell data. Genome Biol 2024, 25:305.
**YOUR TASKS**:
While the genetic components of therapy resistance have been extensively studied in various cancer types, non-genetic, including epigenetic, mechanisms of therapy resistance remain largely unexplored. Multiple mechanisms, including pre-existing persister cells or acquired resistance mediated by cell plasticity, will be tested in experimental model systems and patient-derived material using state-of-the-art single-cell epigenomic technologies.
**YOUR PROFILE**:
We are looking for a highly motivated bioinformatician or computational biologist with a PhD degree, interest in cancer research, and the ability to work in teams with molecular biologists.
- Good knowledge of R and/or Python
- Previous experience in genomic data processing
- Interest in interdisciplinary research
- Knowledge of epigenomic data analysis is a plus
- Fluency in English, German language skills are not required
**WE OFFER**:
**Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level**
**Remuneration according to TV-L incl. occupational pension plan and capital-forming payments**
**30 days of vacation per year**
**Flexible working hours**
**Possibility of mobile work and part-time work**
**Family-friendly working environment**
**Sustainable travel to work: subsidized Germany job ticket**
**Our Corporate Health Management Program offers a holistic approach to your well-being**
**Develop your full potential: access to the DKFZ International Postdoc Program and DKFZ Career Service with targeted offers for your personal development to further develop your talents**
**ARE YOU INTERESTED?**:
Then become part of the DKFZ and join us in contributing to a life without cancer
**Contact**:
Michael Scherer
Phone: +49 6221 42 3309
**Duration**: The position is initially limited to 2 years with the possibility of prolongation.
**Application Deadline**:10.01.2025
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