Phd Student

vor 2 Wochen

Essen, Deutschland Deutsches Krebsforschungszentrum Vollzeit

**Position**:PhD Student - Unraveling the Crosstalk of AHR and Oncogenic KIT in KIT-driven Cancers**

**Department**: DKTK partner site Essen / Düsseldorf - Translational Sarcoma Research Group

**Code number**:2023-0089

The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.

Together with university partners at seven renowned partner sites, we have established the German Cancer Consortium (DKTK).

At the partner site of DKTK Essen / Düsseldorf the German Cancer Research Center is seeking a PhD student to work on a sub-project within the PREDICTAHR DKTK Joint Funding Program. PREDICTAHR aims to comprehensively investigate the aryl hydrocarbon receptor (AHR) with regard to its role as predictive biomarker and exploit its potential use as therapeutic target. There is growing evidence that tumors heavily relying on oncogenic kinases exhibit multiple signaling connections. This project will focus on understanding the crosstalk of AHR and oncogenic KIT in KIT-driven cancers.

**Job description**:

- Cell culture: thaw, culture, split, freeze cells; functional in vitro analyses
- Human cell culture and possibly in vivo experiments
- A broad spectrum of molecular techniques including molecular biology, PCR, qRT-PCR, DNA and RNA isolation, protein isolation and western blot, CRISPR/CAS9, apoptosis assays
- Molecular and flow cytometric study of tumors
- Planning and execution of metabolomics and lipidomics measurements in cell line models
- Development of new methods for the characterization of metabolites and lipids
- Statistical evaluation of results
- Assisted planning and implementation of the project
- Documentation and evaluation of research results as well as preparation of publications, lectures, posters
- Preparation of the dissertation within the PhD project

**Requirements**:

- Background in cancer research, metabolomics and/or related methods
- Experience with lab animals is beneficial
- Knowledge of basic immunological and molecular biology techniques
- Knowledge of metabolite and lipid analysis as well as bioinformatics is desirable

**We offer**:

- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Doctoral student payment including social benefits
- Flexible working hours
- Comprehensive training and mentoring program through the Helmholtz International Graduate School

**Important notice**:
**Earliest Possible Start Date**: as soon as possible

**Duration**: The position is limited to 3 years.

**Application Deadline**:06.04.2023

**Contact**:
Sabine Kaul
Phone +49(0)201/723-2044

The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.

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