Phd Position

vor 3 Monaten


Duesseldorf, Deutschland Universitätsklinikum Düsseldorf Vollzeit

With around 8,000 employees, the University Hospital with its subsidiaries is one of Düsseldorf's largest
employers and is constantly developing. Due to its size and optimal equipment as well as the connection
to research and teaching, the University Hospital offers a wide range of tasks that make the daily work
routine extremely diverse. For this reason, we are looking for motivated people who embrace change
processes and see them as a personal challenge.

The Clinic for Rheumatology and Hiller Research Unit from the Heinrich-Heine-University and University

**PhD position (M/F/d) - Molecular mechanisms of**

**neuroimmunological interactions between schizophrenia and**
**rheumatoid arthritis
**The employment is initially limited for a period of two years but can be extended for an additional third
year. In accordance with -2 Abs. 2 of the Act of Academic Fixed-Term Contract
(Wissenschaftszeitvertragsgesetz - WissZeitVG), the position is limited to the realization of a third-party
funded project.

interactions between rheumatoid arthritis (RA) and schizophrenia in the research group of Dr. Torsten
Lowin at the Department of Rheumatology, Düsseldorf in close collaboration with Prof. Dr. Carsten Korth
of the Institute of Neuropathology, both at the University Hospital Düsseldorf.

The major goal of our group is to characterize pathogenic mechanisms that drive rheumatic diseases
(with focus on rheumatoid arthritis), and to identify novel treatment strategies for this disease. Our
approaches include characterization of the signaling pathways with aberrant function in RA and
validation in animal models of RA.

In this project, we aim to understand the negative epidemiological correlation between Schizophrenia
and RA. We previously identified the regulator of G-protein signaling 1 (RGS1) to be decreased in
patients with schizophrenia but enhanced in patients with RA. We believe that this protein affects many
aspects of the immune response, e. g. the recruitment of immune cells and might therefore be a key
switch and possible therapeutic target in both diseases.

Dr. Lowin’s group is part of an international research group with members from different backgrounds,
including biologists and clinicians, and with close collaborations with researchers from other fields such
as bioinformatics, which ensures an interdisciplinary environment. We have unrestricted access to state
- of-the-art technologies including next generation sequencing, mass cytometry, advanced imaging
techniques and flow cytometry. We thus provide the prerequisites for conducting a challenging, but
highly rewarding PhD project.
from learning interdisciplinary techniques and will have a wide range of possibilities to interact and work
closely with clinical scientists. In addition, the team members will have opportunities to develop their
independent line of investigation for their future career. Certified allowance with animal experimentation
(e.g. FELASA B or equivalent) is preferred but not mandatory.

The position is evaluated according to E 13 Tv-L (65%, 25h weekly)

The employment contract is concluded with Heinrich Heine University.

Heinrich Heine University Düsseldorf aims to increase the proportion of women. Applications from
women with equal suitability, qualifications and professional performance will therefore be given
preferential consideration, unless reasons relating to the person of a competitor outweigh this. The
IX is welcome.

Applications should be written in English and should include:

- believe you can bring to our research group)- curriculum vitae
- attached university diploma
- brief summary of research experience and practical lab skills
- list of referees

University Hospital Düsseldorf and will not be returned for reasons of cost.

If you have further questions, please do not hesitate to contact Dr. rer. nat. Torsten Lowin

**or**

**Universitätsklinikum Düsseldorf**
**D 01.2.1 - reference number: 63E/24**

**Moorenstr. 5, 40225 Düsseldorf



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