Phd Student

vor 2 Monaten


Duesseldorf, Deutschland Universitätsklinikum Köln AöR Vollzeit

as soon as possible
part-time (23,1 hours/week); initially limited until December 31, 2025 WissZeitVG as part of a third-party funded project
Your salary will be based on TV-L
- Your tasks
Investigate how protein homeostasis mechanism affect collagen formation and secretion using human cell lines and state-of-the-art biochemical, proteomics, genetic, and imaging experiments
Identification and characterization factors involved in dealing with malfunctional collagen
Record, analyze, and present experimental data, contributing to scientific publications
Manage your own research project with direct supervision by the PIs
- Your Profile

We are looking for a highly motivated PhD student who holds a Master´s degree in biology or biochemistry. Expertise in tissue culture, microscopy and biochemical analysis are of advantage.
- Our Offer
Close support and method training
Modern laboratories and infrastructure for training and research
A thriving research community, with many internationally-recognized research institutes in direct reach: Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD), Max-Planck Institute for Biology of Ageing, Cologne Center for Genomics, and the Max Planck Institute for Metabolism Research
Access to core facilities offering state-of-the-art technologies (see CMMC facilities and CECAD facilities)
Salary according to the German salary scale TV-L, following the Act of Academic Fixed-Term Contract (Wissenschaftszeitvertragsgesetz - WissZeitVG)
The position is offered for 3 years with the possibility of extension
- Your future with us

Working at the University Hospital Cologne and the Medical Faculty means helping to shape the future - the future of medicine, of patients and, of course, your own future. You benefit from 59 clinics and institutes as well as numerous other departments and facilities and more than 10,000 jobs. The Faculty of Medicine of the University of Cologne and the University Hospital Cologne assume important social tasks in research, teaching and patient care. A close network with many university and non-university partners guarantees an internationally successful science and the excellent education of our students.
- Your future in detail

**Research overview**:
Altered structure or remodeling of the extracellular matrix (ECM) disrupts tissue homeostasis. Cellular quality control mechanisms are therefore essential for the proper assembly and secretion of ECM components. In this context we aim to study how Endoplasmic Reticulum-associated degradation (ERAD) pathway, in synergy with the bulky cargo receptor TANGO1, coordinates proper ECM secretion dynamics. We will also study the consequences of patient-derived mutations in TANGO1 and collagen to unveil novel pathomechanisms and to open novel therapeutic avenues.

**Contact**:
Prof. Dr. Marius Lemberg

**Application deadline**: 08.01.2023

**Postal address**:
Universitätsklinikum Köln AöR
PA16
Geschäftsbereich Personal



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