Phd Position

vor 3 Monaten


München, Deutschland Klinikum rechts der Isar der Technischen Universität München Vollzeit

**Klinikum rechts der Isar der Technischen Universität München (TUM)**

**PhD Position (M/F/d) in T-Cell Immunology**

**full
- or part-time | temporary (24 month) contract | Institut für experimentelle Hämatologie**

The research group of Prof. Marc Schmidt-Supprian at the Institute of Experimental Hematology at the Technical University Munich is seeking a highly motivated PhD student to join our team starting from now onwards. The research project focuses on regulatory T (Treg) cells and investigating their context-specific identity and function in health and B cell-driven autoimmune diseases. This collaborative project is embedded in the Transregional Collaborative Research Centre TRR 355 and aims at integrating the function of regulatory T cells in mice and men and the position is funded for three years.

**Project Overview**:
**The primary objectives include**:

- to compare central Treg cell identity and function programs between mice and men in normal physiology and autoimmunity in collaboration with project partners
- elucidate the transcriptional networks regulated by FoxP3 and c-Rel in Treg cells and screen for novel critical regulators of Treg identity and function in autoimmune contexts
- study how context-specific cytokine milieus affect Treg identity as well as plasticity and functionally validate engineered Treg cells with distinct anti
- or pro-inflammatory features

**Key Responsibilities**:

- Conduct wet lab experiments to generate data describing the context-dependent Treg identity and underlying transcriptional networks.
- Collaborate with project partners.
- Contribute to the preparation and analysis of data for publication and presentations.

**Your profile**:

- Strong background in T cell biology/immunology.
- Hands-on experience with transgenic mouse models, including breeding and colony management.
- Proficiency in preparing and processing lymphoid organs from mice.
- Expertise in Flow Cytometry, particularly in multi-color FACS staining and cell population analysis.
- Experience/Interest in single cell RNA sequencing experiments.
- Excellent proficiency in English, both written and spoken.

**We offer you**:

- EGYM well pass, corporate benefits and discounts (e.g. Käfer), cafeteria, sports and cultural offers, company bike
- Free use of the library through a branch of the Munich City Library located in the building
- Working in the heart of Munich at Max-Weber-Platz with very good accessibility by public transport such as the subway, S-Bahn or tram
- Company pension plan through the Federal and State Pension Institute (VBL)
- Self-realization through a varied and technically demanding job with interdisciplinary cooperation between various departments of the MRI

**Contact: Prof. Mr. Marc Schmidth-Supprian | 089 / 4140 - 4104 | Institut für experimentelle Hämatologie**
- ** reference number 24_09_053**:

- **your preferred starting date.**

Institut für experimentelle Hämatologie

Klinikum rechts der Isar der Technischen Universität München
Ismaninger Straße 22
81675 München


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