Phd Candidate

vor 1 Monat

Heidelberg, Deutschland Universitätsklinikum Heidelberg Vollzeit

In this position, you will be guided to conduct your own project by renowned experts leading a multidisciplinary national cooperation, supported by the German Centre of Cardiovascular Research (DZHK, Innovation cluster) regarding the following topic:
**_ Takotsubo
- and Stroke-heart syndrome: two sides of the same coin?_**
- Takotsubo
- or the Broken-Heart syndrome is often triggered by an episode of severe stress followed by acute heart failure in the absence of coronary obstruction, which may also occur in the so
- called Stroke-heart syndrome early after stroke. Both cause significant mortality and lack a specific therapy. They also share other aspects, including brain regions typically affected, high levels of stress hormones, and myocardial inflammation
- _e. g._
- Nature cardiovascular research 2, 645-655, 2023_). We propose that both syndromes are driven by an overlapping pathophysiology and will compare the functional and molecular features of both syndromes with mechanistic dissection including murine cardiac single-cell sequencing and cell culture studies with our cooperation partners (MDC Berlin, Charité Berlin, University Hospital Mannheim, University Hospital Lübeck).

**Job-ID**:
V000012323

Institut für Experimentelle Kardiologie

**Location**:
Heidelberg

**Start date**:
01.03.2024

**Job Category**:
Science and teaching

**Working hours**:
full-time

**Published**:
25.01.2024

**Limitation**:
Temporary (3 years)

**Contract**:
TV-L

**Your Tasks**:
***
- Planning and conducting preclinical in vivo and in vitro studies together with our technical assistant and MD students
- Communication and coordination of joint studies with collaboration partners
- Basic and advanced cell and molecular biology methods including RNA and protein assays
- Compare the functional features of animal models of both syndromes using echocardiography, telemetry, and invasive hemodynamics (pressure-volume loops)
- Publication in peer-reviewed journals and presentation at national/international meetings

**Your Profil**:
***
- University degree (master) in Biochemistry, biology, human biology, biomedicine, molecular biology, neuroscience, veterinary medicine
- Excellent written and spoken English skills (German skills are optimal, but not required)
- Independent and reliable way of working, outstanding communication skills and team spirit
- High level of commitment, flexibility, and strong sense of responsibility
- Experimental experience with small or large animal models is an asset

**We offer**:
***
- Collectively agreed remuneration, attractive company pension scheme (VBL)
- 30 days vacation
- Sustainable travel: job ticket
- Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
- Wide range of health, prevention and sports offers
- State-of-the-art lab with outstanding scientific and technical infrastructure in an interdisciplinary and family-friendly environment
- Continuous scientific mentoring with ideal conditions to finish your degree within a young, committed academic team

**Contact & Application**:
***

**Interested?**

Institut für Experimentelle Kardiologie
- Dr. med. Bastian Bruns - Leiter Med. Notaufnahme
- Im Neuenheimer Feld 410
- 69120 HeidelbergWe stand for equal opportunities. Severely disabled persons are given priority in the case of equal suitability. The University Hospital aims to generally increase the proportion of women in all areas and positions in which women are underrepresented. Qualified women are therefore particularly encouraged to apply. Full-time positions are generally divisible, unless there are official or legal reasons to the contrary.

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