Manager, Cell Line Development and Process Optimization
vor 3 Wochen
Be part of something altogether life-changing
Working at Cytiva means being at the forefront of providing new solutions to transform human health. Our incredible customers undertake life-saving activities ranging from fundamental biological research to developing innovative vaccines, new medicines, and cell and gene therapies.
At Cytiva you will be able to continuously improve yourself and us – working on challenges that truly matter with people that care for each other, our customers, and their patients. With associates across 40+ countries, Cytiva is a place where every day is a learning opportunity – so you can grow your career and expand your skills in the long term.
Forming part of the Biotechnology segment at Danaher, we bring together dedicated technical expertise and talent to develop the next generation of life-changing therapeutics.
The Manager, Cell Line Development and Process Optimization (d/f/m) for Cytiva is responsible for implementing innovative cell line development processes to advance our proprietary cell line technology.
This position is part of the Cell Line Development R&D team located in Cologne and will be hybrid. At Cytiva, our vision is, to advance future therapeutics from discovery to delivery.
What you will do:
Represent R&D Cell Line Development on internal projects, effectively communicating results, progress and plans with colleagues across departments.
Develop and characterize highly productive stable cell lines suitable for the production of biotherapeutics within project timelines.
Improve cell and process productivity by optimizing the cell line development workflow, increasing production efficiency and reducing costs.
Evaluate and implement new mammalian cell culture technologies to significantly reduce the time from construct to finished clone and improve manufacturing processes.
Optimization of clone screening for the development and optimization of stable cell lines suitable for production.
Generating and analyzing analytical data to support product development, marketing and regulatory submissions. Evaluating genetic characterization of cell banks using molecular techniques such as DNA sequencing and PCR. Integrating data science and modeling solutions into process development.
Ensure smooth and effective transfer of new cell line products and processes to service development teams. Responsible for technical reports, study protocols, technical transfer and regulatory affairs.
Who you are:
Ph.D. or Master’s degree in Cell Biology, Molecular Biology, Biotechnology, Biochemistry, or a related field.
Multiple years of experience in cell line development, with predominant experience on industrial biotherapeutics production and in-depth knowledge of cell line development workflows and technologies.
Demonstrated strong leadership and team management skills, with the ability to provide supervision and guidance to a diverse team.
Extensive experience with quality control (QC) and quality assurance (QA) processes to rigorously ensure the integrity, traceability, and compliance of cell lines.
Excellent communication skills for effectively representing the R&D Cell Line Development team on internal projects and in cross-departmental collaborations.
Strong conceptual understanding and ability to interpret results from various cellular and molecular analytical techniques, such as cell-based assays, ddPCR, NGS, qPCR, and more.
It would be a plus if you also possess previous experience in:
Experience in viral vector production
Good understanding of regulatory requirements and guidelines related to cell line development for biotherapeutics, including ICH, FDA, and EMA guidelines.
At Cytiva we believe in designing a better, more sustainable workforce. We recognize the benefits of flexible, hybrid working arrangements for eligible roles and are committed to providing enriching careers, no matter the work arrangement. This position is eligible for a hybrid work arrangement in which you can work part-time at the Company location identified above and part-time remotely from your home. Additional information about this hybrid work arrangement will be provided by your interview team. Explore the flexibility and challenge that working for Cytiva can provide.
At Danaher we bring together science, technology and operational capabilities to accelerate the real-life impact of tomorrow’s science and technology. We partner with customers across the globe to help them solve their most complex challenges, architecting solutions that bring the power of science to life. Our global teams are pioneering what’s next across Life Sciences, Diagnostics, Biotechnology and beyond. For more information, visit www.danaher.com.
At Danaher, we value diversity and the existence of similarities and differences, both visible and not, found in our workforce, workplace and throughout the markets we serve. Our associates, customers and shareholders contribute unique and different perspectives as a result of these diverse attributes.
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