Researcher with Focus On Circular Rna Biology

vor 2 Wochen


Heidelberg, Baden-Württemberg, Deutschland Universitätsklinikum Heidelberg Vollzeit

wanted for the next possible date at the
Med. Klinik Innere III for the Bioinfomatic & Systemcardiology.


The
Klaus Tschira Institute for Computational Cardiology was founded in September 2015 with funding of the Klaus Tschira Stiftung and is led by Prof.

Dr. Christoph Dieterich.

In the past years, circular RNAs (circRNAs) became a major focus of many studies in animals and plants.

circRNAs are generated by backsplicing from the same linear transcripts that are canonically spliced to produce, for example, mature mRNAs.

They exhibit tissue specific expression pattern and are potentially involved in many diseases, among them cardiovascular diseases.

Job-ID:

V

Klinik für Kardiologie, Angiologie und Pneumologie

Location:

Heidelberg

Start date:

for the next possible date

Job Category:

Science and teaching

Working hours:

Part time (80 %)

Published:

Limitation:

Temporary (1 year / extension is sought)

Contract:

TV-L

Your Tasks:

***- Differentiation and culture of human iPSC-derived cardiomyocytes and standard cell lines (HEK293, HeLa etc.).

  • Molecular cloning of plasmids.
  • Identification and validation of methods to manipulate circRNA expression.
  • RNAprotein pulldown experiments and down stream analysis.
  • Analyze phenotypic effects of circRNA manipulation and cardiac stress.

Your Profil:

***- Sc in Molecular Biology, Molecular Life Sciences or related.

  • Expertise in basic molecular biology techniques (Western blot, RTqPCR) is required.
  • Expertise in cell culture (mandatory), experience in cultivation and differentiation of human iPSCderived cardiomyocytes (preferable).
  • Good written and verbal communication skills in English and German.
  • Willing to work in a multidisciplinary team and able to work independently.

We offer:

***- Goal-oriented, individual training and development opportunities.
Working with the latest techniques / technical equipment.

  • Possibility of mobile working.
  • Flexible working hours within the framework of flexitime.
  • Regular team meetings.

Contact & Application:

***
Interested?
Klinik für Kardiologie, Angiologie und Pneumologie

  • Prof. Christoph Dieterich
  • Im Neuenheimer Feld 669
Heidelberg
- phone: We stand for equal opportunities. Severely disabled persons are given priority in the case of equal suitability. The University Hospital aims to generally increase the proportion of women in all areas and positions in which women are underrepresented. Qualified women are therefore particularly encouraged to apply. Full-time positions are generally divisible, unless there are official or legal reasons to the contrary.

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