Postdoctoral research
vor 1 Monat
Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital. Postdoc Opportunity in Pediatric Leukemia Research: »Drug Discovery and Immunotherapy using pediatric AML patient derived xenografts (PDX)»
(Full time (100%-E13) | limited to 2 years with possibilty of extension | Announcement number: 772-2024
We are seeking a highly motivated postdoc to join our Leukemia Research Group at the Department of Pediatrics (Director: Prof. Our joint labs are at the forefront of pediatric leukemia research, focusing on genetic and epigenetic analyses and pioneering innovative molecularly-guided therapeutic approaches.
This postdoctoral position aims for the discovery and establishment of novel therapeutic options in pediatric acute myeloid leukemia (AML) based on Europe's largest patient-derived xenograft (PDX) biobank for pediatric AML
For an insight into the University Hospital Frankfurt, click here .
Utilizing drug, shRNA, CRISPR-Cas9 and Cas13 libraries, and state-of-the-art cellular immunotherapeutics (NK, CAR-NK, CIK, CAR-CIK, CAR-T) the project aims to establish potent drug targets, drug combinations and cellular immunotherapy that efficiently target AML in vitro and in vivo using these PDX models.
Furthermore, you will maintain and expand the PDX biobank, apply gene expression and single-nucleotide variants (SNV)-based characterization and perform in silico prediction of druggable targets based on these data sources, followed by high-throughput drug testing.
You will also supervise and collaborate with a research technician to ensure smooth laboratory operations.
Flow cytometry and gene expression analysis (RNA-Seq, Western blots) will be central to the project.
The outcomes from this research will contribute to finding novel treatment options for this life-threatening disease.
PhD and publication record in life sciences or related field
Proficiency in spoken and written English
In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes
Excellent scientific environment & dedicated mentoring, training in novel cutting-edge techniques to study epigenetic mechanisms in leukemia cells, collaboration opportunities with national & international world-leading laboratories, participation in training and qualification programs of the MSNZ and the Goethe University
Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice), child care during holidays
Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise.
Professional development: Internal and external training for your professional development
Women are underrepresented in these positions at the University Hospital Frankfurt. Please submit your online application including a possible starting date and your salary expectations. For further information regarding the position and project, please contact: c.hugenberg@kinderkrebsstiftung-frankfurt.Universitätsmedizin Frankfurt | Recruiting Team | Theodor-Stern-Kai 7 | 60590 Frankfurt am Main | Bitte reichen Sie Ihre Bewerbung ausschließlich über den Button »Online bewerben« ein. XING , LinkedIn .
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