Protein Engineer
vor 1 Tag
The successful candidate will be responsible for the design, development, optimization, and scale-up of Protein A affinity ligands and associated purification processes for biopharmaceutical applications.
Key Responsibilities Design and Engineering: Create and engineer Protein A variants with enhanced binding, stability, and selectivity characteristics.Project Leadership: Lead and execute projects aimed at developing and optimizing preparative chromatography processes, including resin screening, column packing, and process scale-up.Collaboration: Work with cross-functional teams in R&D, manufacturing, and quality to ensure smooth technology transfer and robust processes.Analytical Development: Develop and perform analytical assays to characterize Protein A ligands and assess purification performance.Documentation: Clearly document experimental work and contribute to technical reports, patent applications, and regulatory filings.Continuous Learning: Stay updated on advancements in protein engineering, affinity chromatography, and related bioprocessing technologies. Qualifications Education: PhD or MS in Biochemistry, Protein Engineering, Chemical Engineering, Biotechnology, or a related field.Experience: Minimum of 10 years of hands-on experience in protein engineering and preparative chromatography, particularly with Protein A affinity systems.Technical Skills: Proficient in molecular biology techniques, protein expression and purification, and chromatographic method development.Analytical Skills: Strong analytical and problem-solving skills with experience in data analysis and interpretation.Communication: Excellent communication and teamwork abilities. Preferred Experience Experience in the scale-up and manufacturing of chromatography processes.Familiarity with regulatory requirements for biopharmaceutical manufacturing.Knowledge of downstream processing for monoclonal antibodies.This role is vital for advancing the development of purification processes essential for biopharmaceutical applications.
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