Postdoctoral Position in Structural and Functional Analysis of the DNA Helicase DDX11

Vor 7 Tagen

Essen, Nordrhein-Westfalen, Deutschland 895e7d71-01a7-4904-a44b-f5d96828a032 Vollzeit 45.000 € - 60.000 € pro Jahr
Location

Essen

Application area

Department of Biological and Genomic Treatment Approaches

Postdoctoral Position in Structural and Functional Analysis of the DNA Helicase DDX11 (f/m/d, No

EG 13 TV-L

At the interface between human health, the environment and animal health, the Research Center One Health Ruhr provides combines the Departments of Biology, Chemistry, Medicine, Environmental Science and Neuroscience under one interdisciplinary roof. You support the Center for Medical Biotechnology (ZMB) and thereby contribute to the development of the working group of Biological and Genomic Treatment Approaches.

Start of employment

May 2026

Duration of employment

2 years

Working time

39 h 50 min (100%), part-time employment is possible

Your main tasks

The successful candidate will lead a project centered on the purification and structural characterization of the DNA helicase DDX11, a key player in replication-coupled sister chromatid cohesion and genome maintenance. After establishing optimized purification procedures, the project will involve:

  • Structural analysis of DDX11 (in collaboration with cryo-EM and crystallography experts)
  • Functional assays to assess DNA and RNA helicase activity
  • Chemical screening for compounds interfering with DDX11's helicase or DNA-binding functions
  • Biochemical reconstitution of DDX11 interactions with replisome components and cohesin to elucidate mechanistic roles
Your profile
  • PhD in Biochemistry, Structural Biology, Molecular Biology, or related discipline
  • Proven experience in protein purification and biochemical or biophysical assays
  • Experience with structural methods (cryo-EM, X-ray crystallography, or related) is highly desirable
  • Strong motivation, independence, and ability to collaborate across disciplines
We offer you
  • A dynamic, international research environment
  • Access to state-of-the-art structural and proteomics facilities
  • Competitive salary according to German TV-L guidelines
  • Opportunity to contribute to pioneering research at the intersection of DNA replication, repair, and chromatin biology
  • a respectful workplace
  • family-friendliness through care options for your children
  • attractive sports and health services (university sports)
  • an excellent public transport infrastructure and free parking
Application deadline

Code number

629-25

Application

Please send your application indicating the reference number and the subject line Postdoc DDX11 as a single pdf including a motivation letter, CV, publication list, and contact details of two referees to: Prof. Dr. Dana Branzei, University of Duisburg-Essen, Faculty of Biology, Center for Medical Biotechnology (ZMB), 45117 Essen, Germany.

E-mail: dana.-

Research Alliance Ruhr

As the densest university landscape in Europe, the Metropole Ruhr offers attractive career opportunities for excellent scientists from all over the world.

In order to bundle their top international research on the major challenges facing humanity, the Ruhr-Universität Bochum, the TU Dortmund University and the University of Duisburg-Essen founded the Research Alliance Ruhr in 2021. Four research centres and a college have been established here.

This is the latest development in the long-standing cooperation as the University Alliance Ruhr (UA Ruhr), a community of 14,000 researchers and 110,000 students.

Learn more

In accordance with the State Equal Opportunities Act, women with the same qualifications are given referential considered.

Applications from suitable disabled persons and persons of equal status within the meaning of § 2 para. 3 SGB IX are desired.

By applying for one of the advertised positions, you expressly agree to the requirements in accordance with the General Data Protection Regulation and to being contacted by mail. Further information on data protection can be found here.

Back

  • Graduate: Structural Engineering

    vor 1 Woche

    Essen, Nordrhein-Westfalen, Deutschland Hatch Vollzeit 40.000 € - 60.000 € pro Jahr

    Requisition ID: 95780 Job Category: Engineering Location: Essen, North Rhine, Germany Join a company that is passionately committed to the pursuit of a better world through positive change. With more than 65 years of business and technical expertise in mining, energy, and infrastructure, our 10,000 colleagues in 150 countries tirelessly work toward...

  • Market Manager

    vor 2 Wochen

    Essen, Nordrhein-Westfalen, Deutschland The new E Vollzeit 80.000 € - 120.000 € pro Jahr

     E.ON Energy Markets GmbH | Permanent | Full time; Part time E.ON Energy Markets GmbH (EEM) is a subsidiary of the E.ON Group based in Essen. Our main purpose is to coordinate access to trading markets for our regional business units, to bundle the associated chances and risks plus to provide innovative services. Our core competencies include portfolio...

  • Senior Sales Expert and Key Account Manager

    Vor 7 Tagen

    Essen, Nordrhein-Westfalen, Deutschland DNV Vollzeit 60.000 € - 100.000 € pro Jahr

    DescriptionThe Sales Executive is responsible for new Sales executing business development and account management and Key Customer Management within a defined geographical area in the service lines Management System Certification and Training Services with a strong industry focus in line with DNV Business Assurance strategy, contributing directly to revenue...

  • Senior Sales Expert and Key Account Manager

    vor 1 Woche

    Essen, Nordrhein-Westfalen, Deutschland DNV careers Vollzeit 60.000 € - 120.000 € pro Jahr

    The Sales Executive is responsible for new Sales executing business development and account management and Key Customer Management within a defined geographical area in the service lines Management System Certification and Training Services with a strong industry focus in line with DNV Business Assurance strategy, contributing directly to revenue growth and...

  • Application Engineer Software

    Vor 7 Tagen

    Essen, Nordrhein-Westfalen, Deutschland Atlas Copco Vollzeit 60.000 € - 70.000 € pro Jahr

    Application Engineer Software (m/f/d)Functional area: MarketingLocation: GermanyCity: EssenCompany name: Atlas Copco Tools Central Europe GmbHDate of posting: Nov 21, 2025We are looking for a qualified and hands-on person who will support us in increasing the Eco-system sales and market share of our products and solutions in cooperation with the Product...

  • Market Researcher

    Vor 5 Tagen

    Essen, Nordrhein-Westfalen, Deutschland E Vollzeit 60.000 € - 120.000 € pro Jahr

    E.ON SE | Permanent | Full time  E.ON is one of Europe's largest operators of energy networks and infrastructure and a provider of innovative energy solutions. Our employees are constantly working to digitise the energy world, achieve net zero and connect everyone to good energy. To achieve this, we are focusing our actions on sustainability,...

  • Deployment Manager

    Vor 7 Tagen

    Essen, Nordrhein-Westfalen, Deutschland Greenlyte Carbon Technologies Vollzeit 60.000 € - 90.000 € pro Jahr

    Are you ready to save the planet?We help prevent a climate crisis by freeing the world from fossil fuels. Our breakthrough direct air capture (DAC) technology captures CO₂ from the atmosphere and produces hydrogen in parallel.The clock is ticking. What are you waiting for?Our goals are ambitious. To make them real, we need professionals who thrive on...

  • Copy of Copy of Copy of Copy of Major Account Manager

    vor 1 Woche

    Essen, Nordrhein-Westfalen, Deutschland Palo Alto Networks Vollzeit 80.000 € - 120.000 € pro Jahr

    Company Description We're considering Candidates based anywhere in/near northwestern Germany.Our MissionAt Palo Alto Networks everything starts and ends with our mission:Being the cybersecurity partner of choice, protecting our digital way of life.We have the vision of a world where each day is safer and more secure than the one before. These aren't easy...

  • Application Engineer Vision Solutions

    Vor 6 Tagen

    Essen, Nordrhein-Westfalen, Deutschland Atlas Copco Vollzeit 60.000 € - 80.000 € pro Jahr

    Application Engineer Vision Solutions (m/f/d)Functional area: MarketingLocation: GermanyCity: EssenCompany name: Atlas Copco Tools Central Europe GmbHDate of posting: Nov 21, 2025We are looking for a qualified and hands-on person who will support us in increasing the sales and market share of our products and solutions (Atlas Copco Ecosystem) in cooperation...

  • Data Analyst

    Vor 5 Tagen

    Essen, Nordrhein-Westfalen, Deutschland Arsenault Vollzeit 45.000 € - 65.000 € pro Jahr

    Description Good storytelling starts with great listening. At Arsenault, that means each role and every project has our audience in mind. Because the same people who design, develop, and deploy our products also happen to use them. To us, that speaks volumes. About This Role Arsenault is looking for an enthusiastic Data Analyst based in Essen. You will be...