Scientist (m/f/d) – Translational Immunology – as doctoral candidate

Medizin 3

25 Stunden

auf 12 Monate befristet

ab

Eingruppierung gemäß TV-L

Bewerbungsfrist

Universitätsklinikum Erlangen

Medizinische Klinik 3 - Rheumatologie und Immunologie

Ulmenweg 18

91054 Erlangen

Ansprechperson bei Fragen

Sandra Jeleazcov

Leitung Klinik- und Wissenschaftsmanagement

Scientist (m/f/d) – Translational Immunology – as doctoral candidate

Veröffentlicht seit:

Job-Nr.: 12168

Ansprechperson bei Fragen

Sandra Jeleazcov

Leitung Klinik- und Wissenschaftsmanagement

Anschrift

Universitätsklinikum Erlangen

Medizinische Klinik 3 - Rheumatologie und Immunologie

Ulmenweg 18

91054 Erlangen

Scientist (m/f/d) – Translational Immunology – as doctoral candidate

Veröffentlicht seit:

Job-Nr.: 12168

Universitätsklinikum Erlangen

Medizinische Klinik 3 - Rheumatologie und Immunologie

Ulmenweg 18

91054 Erlangen

Ansprechperson bei Fragen

Sandra Jeleazcov

Leitung Klinik- und Wissenschaftsmanagement

Klingt spannend?

Das sind wir:

Apply now to join our team as a doctoral candidate and become part of the CRC/SFB 1755 CASCAID "Cellular and Systems Control of Autoimmune Disease". CASCAID is an interdisciplinary Collaborative Research Centre funded by the German Research Foundation (DFG).

CASCAID is dedicated to developing novel strategies for sustained drug-free remission in autoimmune and chronic inflammatory diseases with a focus on arthritis, lupus and inflammatory bowel diseases by identifying and characterising dysregulated immune-cell networks and tissue programmes.

CASCAID offers a unique clinically anchored and internationally connected collaborative research environment. Erlangen is one of the leading centres for clinical centred research in the field of immunology in Europe and offers access to all state-of-the-art technological platforms.

We are offering several PhD positions across various interdisciplinary projects:

Option 1: This project investigates whether tissues truly return to their physiological baseline after inflammation or retain persistent structural alterations that influence future disease susceptibility. Utilizing innovative 3D imaging and AI-driven analysis, the study maps cellular niche restoration and tissue remodeling to define the requirements for genuine histological healing beyond mere clinical remission.

Option 2: This research project investigates how CD19-CAR T-cell therapy achieves long-term remission in autoimmune diseases by restructuring the stromal environment within lymph nodes. By comparing CAR T-cells with conventional treatments, the study aims to characterize how the "resetting" of various stromal cell populations and follicular structures contributes to a permanent cure.

Option 3: This project investigates how CD19-CAR T-cell therapy restores healthy skin architecture and halts fibroblast activation in systemic sclerosis. Using spatial omics and advanced imaging, the study identifies molecular drivers of tissue regeneration to define markers for deep histological healing.

Option 4: This research project investigates "inflammatory fibroblast memory" by examining why activated fibroblasts persist in patients with arthritis even after successful treatment. Using gene editing in mouse models and comparative molecular profiling, the study explores how these persistent cells trigger relapses and chronic damage.

Option 5: This project establishes a centralized infrastructure combining high-resolution tissue imaging with AI-driven analysis to understand the spatial dynamics of remission and relapse in autoimmune diseases. By integrating imaging and omics data, it visualizes complex tissue processes that remain hidden using conventional methods. The goal is to set new computational standards for researching inflammatory mechanisms and genuine tissue healing.

Doctoral researchers in CASCAID will be integrated into graduate school, which teaches soft and hard skills beyond the research work in the host laboratory and offers a unique infrastructure for team building and exchange opportunities for doctoral students. Doctoral candidates are further supported by a thesis mentoring committee and will benefit from career development support.

Your tasks:

Processing complex tissue and patient samples for molecular analysis

Conducting functional studies in cell culture models or preclinical systems to validate therapeutic mechanisms

Processing and interpreting extensive data sets

Testing hypotheses through experiments in cell cultures or experimental models

Essential experience/qualifications:

Master's degree (or equivalent) in immunology, molecular biology, biochemistry or a related field, either held or due to be completed at the time of application

Strong interest in immunological research

Analytical thinking and the ability to work independently

High level of motivation and commitment

Fluent written and spoken English

We offer:

Employment in accordance with TV-L (collective agreement for the public sector) based on DFG standards

The opportunity to make a significant research contribution to publication-oriented projects and to write high-quality manuscripts

Excellent access to state-of-the-art technologies

Support in presenting your work at international conferences to exchange ideas with the international scientific community

A strong network of internationally renowned collaborators

Arbeiten am UKER

Wir zählen zu den besten Krankenhäusern Deutschlands und sind einer der größten Arbeitgeber in Mittelfranken. Diesen Erfolg erarbeiten tagtäglich unsere über hoch qualifizierten Beschäftigten in unterschiedlichsten Berufen. Wir als Uniklinikum Erlangen wissen, dass alle unsere Beschäftigten wichtig sind, damit auch in Zukunft modernste Medizin, ausgezeichnete Forschung und Patientenversorgung auf höchstem Niveau gelingen.

Wenn Sie sich eine Tätigkeit mit einem hohen sozialen Wert wünschen und die Welt der Spitzenmedizin mit uns gemeinsam gestalten und ermöglichen möchten, dann sind Sie bei uns richtig

Was meinen Sie? Passen wir zu Ihnen und Sie zu uns ans Uniklinikum Erlangen?

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