Proteomics Expert, Senior Scientist

vor 1 Woche


Frankfurt am Main, Hessen, Deutschland Merck KGaA Vollzeit 80.000 € - 120.000 € pro Jahr

Work Your Magic with us

Ready to explore, break barriers, and discover more? We know you've got big plans – so do we Our colleagues across the globe love innovating with science and technology to enrich people's lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

Your role

  • We are looking for a highly motivated scientist to join our proteomics team within the Discovery Pharmacology Department. The Department focuses on hit discovery and hit optimization up to candidate nomination of small molecules drugs and ADCs with novel payloads for Oncology and Neuroscience diseases. You will work alongside colleagues with expertise in compound management, high-throughput screens, cell-free and cellular assays, biophysics and structural characterization.
  • Your role focuses on proteomics data generation and includes running the daily operation and maintenance of a state-of-the-art proteomics infrastructure (Evosep ONE, TimsTOF MPP) including automated sample processing devices (liquid-handling robot and others). You will plan and perform proteomics experiments as well as analyse and communicate the resulting data within scientific project teams. Furthermore, you will implement new methods for innovative projects and continuously streamline internal proteomics workflows to strengthen our drug discovery pipeline and support our various project teams.
  • Another important part of your work will be managing drug discovery projects including development of molecular glues, PROTACs, degraders, covalent leads, inhibitors and novel ADCs payloads for clinically validated but also very innovative targets. You will be part of collaborative multi-functional drug teams including biology, chemistry, data scientists, DMPK and safety experts focusing on the discovery of life changing medicines. You will be integrated in a dynamic environment, including external collaborations with CROs to accelerate drug discovery.

Who you are:

  • You hold a university degree (Ph.D) in a life science discipline with several years of experience in the biopharmaceutical or related industry, ideally in proteomics and project leading skills is desirable.
  • Teamwork is a central part of how you love to function and thrive. You're looking to be part of a dynamic and growing organization where you want to influence your own development. You are passionate about being an essential piece of the drug discovery process.
  • Hands-on experience in MS-based proteomics (sample preparation, instrument maintenance/troubleshooting, data analysis).
  • Experience in label-free DDA and DIA(-PASEF) based peptide and protein quantification, ideally including the analysis of PTMs.
  • Capabilities in performing analysis and visualization with R and/or Python would be a plus.
  • Research experience in the fields of oncology, immuno-oncology or immunology is advantageous.
  • Excellent presentation and communication skills, both written and verbal. You are fluent in English.
  • Collaborative mindset with very good analytical skills to solve problems, both by yourself as well as by leading and helping others are among your strengths.
  • Strong interpersonal skills that allow you to effectively interact with stakeholders from various teams and areas, both in German and in English are key attributes.

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity



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