PhD Position

Vor 3 Tagen

Köln, Nordrhein-Westfalen, Deutschland Uniklinik Köln Vollzeit 32.000 € - 40.000 € pro Jahr

PhD position in Translational Cancer Immunology

Center for Molecular Medicine Cologne

•
AG Schlößer

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Cologne Translational Immunology

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Department of General, Visceral, Thoracic, and Transplantation Surgery

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University of Cologne

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Faculty of Medicine

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University Hospital Cologne

•
Cologne, Germany

The University of Cologne is one of the largest and oldest universities in Europe and one of the most important employers in our region. Our broad range of subjects, the dynamic development of our main research areas and our central location in Cologne make us attractive to students and researchers from around the world. We offer a wide range of career opportunities in science, technology, and administration.

The Schlößer laboratory at the Center for Molecular Medicine Cologne works on translationally relevant mechanisms of immune evasion in solid cancers. The specific project focuses on B cells, which represent an important component of the tumor microenvironment and affect naturally occurring anti-tumor immune responses as well as cancer immunotherapies. While the production of antibodies is well characterized in the context of infectious diseases and cancer, many aspects of antigen-presenting B-cell functions need further investigation. We aim to elucidate the role of antigen-presenting B cells and B-cell mediated T-cell responses in immunosurveillance of gastric cancer.

Your Tasks

  • Comparison of immunopeptidome derived from different antigens and processed by different sources of antigen-presenting cells
  • Characterization and phenotyping of induced tumor-specific T-cell responses
  • B-cell receptor and T-cell receptor sequencing
  • In vitro cytotoxicity experiments and testing the influence of specific drugs on the antigen-presenting capacity

Your Profile

  • Excellent MSc degree in biology, biotechnology, or a related field
  • Strong interest in translational research in immuno-oncology
  • Expertise in at least one of the following fields: Cell culture, bioinformatics or flow cytometry
  • Applicants should be highly motivated, independent and have strong communication skills
  • Knowledge of immunological processes is a plus but not a prerequisite

We offer

  • A friendly and motivated work environment in a long-standing team of experienced biologists
  • Close relation with clinicians and a focus on translationally relevant research questions
  • Support and training in several cutting-edge immune assays in a positive environment
  • A joint graduate school of the medical faculty and the faculty of natural sciences (IPMM)

The position is available from and is to be filled for three years with the possibility of an extension. The salary will be based on remuneration group 13 TV-L of the pay scale for the German public sector. According to the standards in Germany, PhD-students receive part-time contracts (65%).

Please send your application to: hans.-

Branche

  • Krankenhäuser und Gesundheitseinrichtungen

Beschäftigungsverhältnis

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