Senior) Bioinformatician

**Reference number**:2025-0109** - Dresden - Full-time - Translational Medical Oncology **_“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be diagnosed more precisely and cancer patients can be treated more successfully. Every contribution counts - whether in research, administration or infrastructure. This is what makes our daily work so meaningful and exciting._** One of the six NCT sites is the NCT Dresden (NCT/UCC), which is a collaboration between the DKFZ, the University Hospital Carl Gustav Carus Dresden (UCC), the Carl Gustav Carus Medical Faculty of the TU Dresden and the Helmholtz Center Dresden-Rossendorf (HZDR). The **Department for Translational Medical Oncology** is looking for as soon as possible a NCT and DKFZ have laid the groundwork to address new challenges in personalized oncology through the MASTER program. This prospective registry trial employs very comprehensive molecular profiling and integrated data analysis (WGS/WES, RNA sequencing, genome-wide DNA methylation profiling; whenever possible mass spectrometry-based (phosphor)proteomics, ex vivo drug sensitivity profiling and spatial resolution of the immune environment). Based on the MASTER workflow we provide clinically relevant management recommendations in a multicenter molecular tumor board (MTB) and follow-up on clinical management of patients. The resulting multidimensional clinical and molecular dataset has kick-started very successful interdisciplinary research projects (e.g. Heining et al. Cancer Discov 2018, Gröschel et al. Nat Commun 2019, Horak et al. Cancer Discov 2021, Möhrmann et al. Nat Commun 2022, Jahn et al. Ann Oncol 2022). **YOUR TASKS**: **YOUR PROFILE**: Applicants should - hold a PhD degree (postdocs) in bioinformatics or/and life sciences, with an excellent background in NGS analysis and relevant experience in the field. - have background knowledge in cancer genomics - be proficient in bash scripting and R and experience with cloud computing (required) - be proficient with Python and Git (preferred) - perform bioinformatical and statistical analysis of multi-tier molecular profiling data including NGS and single cell NGS and drive the development and implementation of new technologies. - be highly self-motivated and be able to develop and pursue research projects independently as well as in collaborations. - have excellent written and oral command of English and strong communication skills. German language skills are not required. Applications should include a CV, cover letter, certificates, expected availability date, a complete list of publications and 2-3 references. **WE OFFER**: **Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level** **30 days of vacation per year** **Flexible working hours** **Remuneration according to TV-L incl. occupational pension plan and capital-forming payments** **Possibility of part-time work** **Family-friendly working environment** **Sustainable travel to work: subsidized Germany job ticket** **Unleash your full potential: targeted offers for your personal development to further develop your talents** **Our Corporate Health Management Program offers a holistic approach to your well-being** **ARE YOU INTERESTED?**: Then become part of the DKFZ and join us in contributing to a life without cancer **Contact**: Julia Dorok Phone: 0351-4585527 **Duration**: The position is initially limited to 2 years with the possibility of prolongation. **Application Deadline**:07.05.2025