Phd Position

vor 1 Woche


Jülich, Deutschland Forschungszentrum Jülich Vollzeit

**Your Job**:
The Solute Carrier family 26 (SLC26) includes functionally versatile anion transporters that are of pathophysiological relevance in the gastro-intestinal tract, kidney and lung. SLC26A11 stands out among the ten functional homologs present in humans because of the pH dependency of its chloride/sulfate exchange and the presence of a unique glutamate residue in the anion binding site, suggesting a novel proton-coupled transport mechanism. Expected Results:

- Investigation of the molecular mechanism of proton transfer in SLC26A11
- Performing molecular dynamics simulations, both classical and quantum mechanics/molecular mechanics
- Employing enhanced sampling methods like metadynamics
- Analysis and interpretation of the results and design of further simulations
- Exchange with internal as well as external project partners, both national and international
Preparing scientific publications and project reports and presentation at conferences

**Your Profile**:

- University degree (Master) in Chemistry, Biochemistry, Biology, Physics or related fields
- Experience with UNIX-like operating systems
- Ideal prior knowledge on MD simulations and QM/MM
- Excellent knowledge of written and oral English: TOEFL or equivalent evidence of English-speaking skills
- Interactive person with good communication and organizational skills for exchange with colleagues and cooperation partners
- Used to work in international and interdisciplinary teams

**Our Offer**:
We work on the very latest issues that impact our society and are offering you the chance to actively help in shaping the change We offer ideal conditions for you to complete your doctoral degree:

- Outstanding research and computing infrastructures, with one of Europe's largest supercomputing facilities
- Comprehensive training courses and individual opportunities for personal and professional further development
- Ideal conditions for balancing work and private life, as well as a family-friendly corporate policy
- Flexible work (location) arrangements, e.g. remote work
- Part-time position with 19,5 hours per week and flexible working hours
- 30 days of annual leave (depending on agreed working time arrangements) and provision for days off between public holidays and weekends (e.g. between Christmas and New Year)



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