Post Doc

**The Position**:
**Join Us in Shaping the Future of Obesity Research**

We are seeking a passionate and talented postdoctoral researcher who shares our ambition to uncover innovative therapeutic strategies for the treatment of obesity. We aim for in-depth investigation of critical neuronal and molecular mechanisms that could enhance and prolong the efficacy of anorexigenic therapeutics. Using cutting-edge technologies such as patch clamp and functional biosensor imaging in acute brain slices, you will explore how neuronal networks respond to pharmacological modulation.
As a neuroscience expert, you will contribute to interdisciplinary discussions and help expand our fundamental understanding of brain-mediated control of energy homeostasis.

This position is part time eligible with min. 90%.

This Position is limited for 2 years.

**Tasks & responsibilities**:

- In your new role, you will investigate cellular and molecular changes in circumventricular brain areas during the development of obesity and in response to anti-obesity treatments.
- Furthermore, you will explore single-cell sequencing datasets for markers that predict sustained suppression of food intake through neuronal and network responses.
- You will establish and perform methods for AAV-mediated transduction of hypothalamic nuclei in mice, including labeling specific neuron populations and monitoring plastic network changes upon pharmacological treatments.
- In addition, you will set up and execute experiments to study neuronal properties in hunger/satiety circuits using electrophysiology techniques, such as cell-attached or whole-cell patch clamp and functional imaging in acute brain slices.
- You will present your findings at internal and external meetings and publish them in peer-reviewed journals.
- Moreover, you will collaborate in a stimulating environment with experts in the field and be part of interdisciplinary teams involving cellular and molecular biologists, chemistry experts, electrophysiologists and pharmacologists.

**Requirements**:

- PhD in biology, neuroscience, or related fields in-depth knowledge in neuroscience
- Extensive hands-on experience in whole-cell patch clamp and electrophysiology recordings in acute brain slices; background in recording hypothalamic and/or brainstem neurons is advantageous
- Solid understanding of neurophysiology and experience in viral approaches to transduce rodent brain; stereotaxic surgery knowhow would be a plus
- Demonstrated track record of publications in scientific journals
- Ability to work in a drug-discovery oriented environment with multidisciplinary teams
- Fluency in English (written and spoken); German language skills are desirable

**Ready to contact us?**:
Recruitment process:
Step 2: Virtual meeting in the period from mid till end of November
Step 3: On-site interviews beginning of December