Postdoctoral Researcher in Computational Genetics

The research group of

Oliver Stegle

looks for a postdoctoral researcher to join a collaborative project with

GSK

Our research group is pioneering computational methods for deciphering molecular variation across individuals, space, and time. We have a track record in the development of computational methods for genetics, high-throughput omics data and causal discovery. Our interdisciplinary and international team is jointly located at DKFZ and EMBL Heidelberg, and is connected to the vibrant local ecosystem for data science, machine learning and computational biology in Heidelberg (including

ELLIS Life Heidelberg

and the

AI Health Innovation Cluster

).

Your role

DeepRVAT

Possible directions within this project include:
- Extending DeepRVAT towards non-coding genetic variation-
- Integrating population data with experimental perturbation datasets

You have- A PhD or equivalent qualification in computer science, statistics, mathematics, physics, and/or engineering, or a degree in biological science with demonstrated experience in computational and statistical development.- Experience with implementing statistical learning or machine learning (e.g. Bayesian inference, deep-learning).- Programming skills in Python and experience with frameworks like PyTorch, Keras, Pyro or TensorFlow.- The motivation and dedication to lead a scientific project and you are a supportive, creative and responsible team member.

You may also haveRecent publications:
- Clarke, B., Holtkamp, E., et al. Integration of variant annotations using deep set networks boosts rare variant association testing. Nature Genetics (2024)- Marconato, L., Palla, G., Yamauchi, K. A., Virshup, I., et al. SpatialData: an open and universal data framework for spatial omics. Nature Methods (2024)- Velten, Britta, et al. Identifying temporal and spatial patterns of variation from multi-modal data using MEFISTO. Nature Methods (2022)- Kleshchevnikov, Vitalii, et al. Cell2location maps fine-grained cell types in spatial transcriptomics. Nature Biotechnology (2022)- Argelaguet, R., et al. Multi-Omics factor analysis disentangles heterogeneity in blood cancer. Molecular systems biology (2018)

Further information- Contract duration: This position is a 2 year contract, renewable to a maximum of 5 years. Professional development support

The EMBL Fellows’ Career Service provides support and guidance to predoctoral and postdoctoral fellows across all six EMBL’s sites.

Working with a dedicated Careers Advisor, this invaluable service will help you to take informed decisions about your career planning both in the short and longer term. Whether your main interest is pursuing a career path in academia, exploring opportunities in industry or exploring an independent venture, the EMBL Fellows’ Career Service with provide you with a portfolio of activities and resources to help you.

Why join us

Join a culture of innovation
We are located on the Wellcome Genome Campus, alongside other prominent research and biotech organisations, and surrounded by beautiful Cambridgeshire countryside. This is a highly collaborative and inclusive community where our employees enjoy a relaxed atmosphere. We are committed to ensuring our employees feel valued, supported and empowered to reach their professional potential.

Enjoy lots of employee benefits:
- Financial incentives: Monthly family and child allowances, generous stipend reviewed yearly, pension scheme, death benefit and unemployment insurances- Flexible working arrangements including hybrid working patterns- Private medical insurance for you and your immediate family- Generous time off: 30 days annual leave per year in addition to public holidays- Campus life: Free shuttle bus to and from work (Heidelberg), on-site library, subsidised on-site gym and cafeteria, casual dress code, extensive sports and social club activities (on campus and remotely)- Family benefits: Kindergarten (Heidelberg), 10 days of child sick leave, paid maternity & parental leave, holiday clubs on campus and monthly family and child allowances

What else you need to know-
- international applicants

.-
- Job location: All our fellowships are based on-site (for at least part of each week). If you are living overseas, you will receive a generous relocation package to support you.-
- here Closing Date

14/03/2025