In Silico Biology Scientist

vor 1 Woche


Aachen, Deutschland Grünenthal Vollzeit

**Country**:Germany**City**:Aachen**Department**:Research & Development**Job ID**:43042- If you’re passionate about changing lives for the better, this is the opportunity you’ve been waiting for. In - **Research & Development**, we’re continuously exploring innovative new treatment options to make a stronger, more positive impact on the lives of the patients we serve. You’ll work with talented colleagues in a state-of-the-art Research & Development environment, developing innovative medicines that change the live of patients for the better and help us make progress towards our vision of a world free of pain. Join us today, and discover the difference you can make.**What the job looks like** Each day you'll enjoy a variety of challenges, such as: - Drive implementation of innovative computational methods and techniques for identifying novel pain pathway and target insights, translational biomarkers and patient stratification - Deliver data analytic platform to integrate single cell multiomicsfunctional genomics, patient-level data leveraging AI/ML/DL techniques to identify novel drug targets in pain - Correlate genomic data (human genetics and functional genomic datasets) against clinical/patient phenotypic data to discover novel pain disease insights and biomarkers for response/resistance to therapy - Present and communicate key findings to relevant stakeholders to enable data-driven decision making across research pipeline. - Ensure findings from computational biology work are appropriately incorporated into the asset strategies and more specifically into clinical translation and early clinical development plan (CDP) for the asset - Initiate, design and establish external collaborations anchored in in silico biologys to inform target selection, efficacy/safety assessment and de-risking of assets - Be responsible to integrate other efforts within our research group focused on human cell-based models and systems biology **What you'll bring to the table** To make the most of this role and truly thrive, you should have: - PhD in computational biology/bioinformatics/systems biology with either postdoctoral or relevant industry experience - Demonstrated recent ability to design and lead human omics studies (with a variety of study designs) delivering novel and actionable findings with measurable impact on R&D pipeline (e.g. generated novel targets/projects that advanced to clinical stage, identification of biomarkers used in pre/clinical settings) - Proven expertise in working with multiple omics data sets at bulk and single cell resolution - Expert in programming with R and/or Python - Broad experience in training and evaluating machine learning models leveraging frameworks such as Tensorflow, Keras, Pytorch - Prior experience with high performance computing environments and cloud technology - In depth knowledge of various external databases employed in omics & systems biology research to be able to explore their applicability for Grunenthal portfolio - Fluent business English language skills in speaking and writing, German language skills beneficial - Broad international & intercultural working experience **What are some of the local benefits** - Hybrid working model - Bilingual daycare centre "Karlinis" and holiday activities for employees' children - 30 holidays, plus 6-8 bridging days and possibility to convert salary into up to 5 additional holidays - (E-) Bike leasing and e-charging stations Chanchal Kumar, the Hiring Manager



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