Aktuelle Jobs im Zusammenhang mit Postdoc for the Division of Personalized Immunotherapies - Mainz - DKFZ
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Mainz, Deutschland Deutsches Krebsforschungszentrum (DKFZ) VollzeitThe German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members. The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and...
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Mainz, Deutschland Deutsches Krebsforschungszentrum (DKFZ) VollzeitThe German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members. The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and...
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Mainz, Rheinland-Pfalz, Deutschland Deutsches Krebsforschungszentrum Vollzeit 45.000 € - 60.000 € pro JahrReference number: MainzFull-timeHI-TRON Mainz - Personalized ImmunotherapiesThe German Cancer Research Center (DKFZ) is one of Europe's largest cancer research centers. "Research for a life without cancer" is the mission of our world-class scientists and all our team members.The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to...
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Mainz, Deutschland Deutsches Krebsforschungszentrum Vollzeit**Reference number**:2025-0252** - Mainz - Full-time - HI-TRON Mainz - Personalized Immunotherapies **_“Research for a life without cancer" is our mission at the German Cancer Research Center. We investigate how cancer develops, identify cancer risk factors and look for new cancer prevention strategies. We develop new methods with which tumors can be...
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Mainz, Deutschland DKFZ VollzeitJunior Research Group Leader "Translation of Next Generation Anti-Cancer Cellular Immunotherapies“ Reference number: 2025-0281 Mainz Full-time DKTK partner site Frankfurt/Mainz - Department of Hematology and Medical Oncology at the UMC Mainz The German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a...
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Mainz, Deutschland Deutsches Krebsforschungszentrum (DKFZ) VollzeitThe German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members. The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and...
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Mainz, Deutschland Deutsches Krebsforschungszentrum (DKFZ) VollzeitThe German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members. The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and...
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Mainz, Rheinland-Pfalz, Deutschland Deutsches Krebsforschungszentrum Vollzeit 60.000 € - 120.000 € pro JahrReference number: MainzFull-timeDKTK partner site Frankfurt/Mainz - Department of Hematology and Medical Oncology at the UMC MainzThe German Cancer Research Center (DKFZ) is one of Europe's largest cancer research centers. "Research for a life without cancer" is the mission of our world-class scientists and all our team members.The DKFZ is a place where the...
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Senior) Research Associate
vor 2 Wochen
Mainz, Deutschland TRON – Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz Vollzeit(SENIOR) RESEARCH ASSOCIATE (M/F/d) _ - Full time - Mainz_ We are seeking an experienced **(Senior) Research Associate** to join our **Immunomodulation Unit** in the **Department of Immunotherapy**. In this role, you will work with both **preclinical mouse models** and **human** **samples**, contributing to the development of innovative immunotherapies...
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Technical Assistance/research Associate, Referenz:
vor 2 Wochen
Mainz, Deutschland TRON VollzeitTECHNICAL ASSISTANCE/ _ - RESEARCH ASSOCIATE (M/F/D) _ - Full time - Mainz_ We are looking for support in our **Animal Models & Imaging** unit to start as soon as possible. The successful immunotherapies (e.g. antibody-based therapies, RNA-based vaccines, combination therapies) against cancer and other diseases. **Your tasks and...
Postdoc for the Division of Personalized Immunotherapies
vor 2 Wochen
Postdoc for the Division of Personalized Immunotherapies Reference number: 2025-0293 Mainz Full-time HI-TRON Mainz - Personalized Immunotherapies The German Cancer Research Center (DKFZ) is one of Europe’s largest cancer research centers. “Research for a life without cancer" is the mission of our world-class scientists and all our team members. The DKFZ is a place where the brightest minds pursue bold ideas and seek answers to pioneering scientific questions through collaboration, innovation, and exploration across many disciplines. We provide a dynamic environment which empowers excellence with state-of-the-art technologies, cutting edge infrastructure, and a global scientific network. Contribute your knowledge, vision, and dedication to create a space where scientific discovery in cancer research is transformed into benefits for human health. The Helmholtz Institute HI-TRON is a collaboration of the German Cancer Research Center with the Research Institute for Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz (TRON gGmbH), the University Medical Center Mainz and the Johannes Gutenberg University Mainz. The goal of the partnership is to develop effective immunotherapies and to identify novel biomarkers for assessing the effectiveness of treatment.To strengthen the HI-TRON team in Mainz, we are seeking for the next possible date a skilled and motivated The Division of Personalized Immunotherapy (headed by Prof. Dr. Özlem Türeci) at HI-TRON Mainz is looking for an individual with a strong background in oncoimmunology and a passion for developing innovative immunotherapies. The successful candidate will be instrumental in advancing fundamental knowledge and creating novel technologies to improve responsiveness to immune checkpoint inhibitors via cell-specific mRNA delivery. Your Tasks Project Summary:Exhausted CD8⁺ T cells in human tumors represent a highly heterogeneous population composed of multiple functional and developmental subsets. Recent studies identified a precursor/progenitor exhausted T cell subset characterized by TCF-1 expression, proliferative potential, and multilineage differentiation capacity. These cells serve as the critical reservoir that gives rise to intermediate and terminally exhausted subsets, which, although cytotoxic, display high inhibitory receptor expression and limited persistence.Notably, clinical responses to anti–PD-1 immune checkpoint blockade correlate strongly with the presence and expansion of these precursor/progenitor exhausted CD8⁺ T cells. However, a substantial proportion of patients fail to respond despite tumor-infiltrating CD8⁺ T cells, suggesting that the composition of exhausted T cell subsets — not merely their presence — is a determinant of therapy success.This project aims to expand precursor/progenitor exhausted CD8⁺ T cells through enforced expression of specific transcription factors using targeted mRNA delivery technologies, with the vision of enhancing responsiveness to immune checkpoint inhibitors.Key Responsibilities:Design, execute, and optimize functional and phenotypic assays on human T cells (in vitro and ex vivo).Engineer T cells using mRNA delivery platforms via lipid nanoparticlesCharacterize T cell subsets using multiparametric flow cytometry and single-cell omicsEvaluate T cell stemness, exhaustion signatures, proliferative potential, and effector function (killing assays, cytokine profiling, transcriptomics)Perform murine in vivo studies, including tumor implantation, treatment studies, tissue processing, and extensive immune profilingCollaborate within a multidisciplinary team, present data internally and externally, and contribute to manuscripts and grant proposalsMaintain accurate laboratory documentation and adhere to biosafety and ethical standardsMentor junior scientists Your ProfileRequired Qualifications:Master's degree (M.Sc.) and PhD in immunology, cancer biology, molecular biology, biomedical sciences, or a related disciplineProven expertise in T cell biology, including activation, exhaustion, or immunotherapyHands-on experience with primary immune cell culture and flow cytometry-based phenotypingExperience with mouse models, including handling, injections, harvesting tissues, and processing tumor/immune samplesFELASA or equivalent animal experimentation certificationStrong troubleshooting ability, scientific rigor, and motivation for translational immunologyPreferred/Desirable Skills:Experience with mRNA expression systems, gene delivery, or viral/non-viral engineeringFamiliarity with single-cell (scRNA-seq/ATAC) or spatial technologiesBackground in tumor models, checkpoint therapy, or T cell differentiationExcellent communication and teamwork skillsPlease submit:Cover letter describing motivation and relevant expertiseCV with publication list
