PhD Student Chemistry, Biochemistry, Biology
vor 2 Wochen
Limited to 3 years | Part-time with 65 % | Salary according to salary group 13 TV-L | Physiological Chemistry and Pathobiochemistry | Job ID:
We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.
To meet our high standards every day, we are looking forward to your scientific expertise in Physiological Chemistry and Pathobiochemistry. Here, Prof. Seraphine Wegner is currently looking for motivated doctoral candidates with an active interest in interdisciplinary research in the area of intelligent materials and synthetic cells. The doctoral candidates will be part of the Collaborative Research Center (CRC) “Intelligent Matter: From Responsive to Adaptive Nanosystems at the University of Münster” - ideally with you on board
The project involves the development of “Multistimuli sensing with memory and feedback function using photoswitchable proteins”. We aim to develop molecular systems starting from photoswitchable proteins as well as model membranes and synthetic cells that can integrate multiple stimuli (different colors of visible light, chemical fuels, temperature etc.) and respond to these. We will explore how such systems can develop memory for previous inputs, use intrinsically generated signals to generate feedback and show nonlinear dynamic responses. Our goal is to harness the established molecular toolbox of different light-responsive proteins and their photoactivation with in situ generated light for seamlessly integrating these proteins into reaction networks, creating systems that demonstrate adaptive and pulsatile responses. As demonstrators, we plan to incorporate the photoswitchable proteins and reactions into diverse soft material systems including protein aggregates, supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs). The first focus will revolve around reaction networks with light responsive elements that can be fueled with external light illumination as well as in situ light production modules in the form of chemiluminescence and bioluminescence reactions. The second emphasis will be to produce systems with transient pulsatile responses to changes in illumination, moving beyond a simple binary on/off response. More details on the research profile of the group.
Your Tasks- Design and characterization of photoswitchable proteins, protein and DNA based biochemical techniques
- Formation of biomimetic surfaces with precise biofunctionalization
- Investigation of light controlled and chemically fueled systems
- Fluorescence microscopy and image analysis
- A Master’s of Science Degree (and no previous PhD degree) in Chemistry, Biochemistry or related fields
- Advanced level training in science and technology of relevance to the specific PhD position, including relevant laboratory experience
- Motivation to work at the interface of disciplines (Chemistry, Biology, Engineering and Physics)
- Communication and reporting skills, and interest for the promotion of science
- Exciting Projects
- Professional Development and Training
- Interdisciplinary Collaboration
- Part of Research Innovation
- Additional Benefits
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