PhD Researcher in Functional Omics of Ageing and Age-Related Diseases

vor 2 Wochen


Bonn, Deutschland Dzne Vollzeit

We are seeking a highly motivated and skilled researcher to join our team at the German Center for Neurodegenerative Diseases (DZNE) in Bonn. The successful candidate will be part of the Population Health Sciences group, led by Prof Dr Monique M B Breteler, and will contribute to our research on the functional omics of ageing and age-related diseases.

The research is primarily based on the Rhineland Study, a prospective cohort study that emphasizes deep phenotyping. The study currently includes more than 11,000 participants at baseline, follow-up data is already available from nearly 5,000 participants, and further data collection is ongoing. Available clinical data include detailed structural and functional brain imaging, cognitive and neurological assessments, cardiovascular and anthropometric assessments, sensory systems tests, medical history, and medication use. We further have detailed exposome data, including information on physical activity, diet, and environmental toxin and temperature exposure.

The successful candidate will integrate different layers of OMICS data (both cross-sectional and longitudinal) to investigate biological questions related to health outcomes with a specific focus on neurodegeneration. Responsibilities include participation in and supervision of data acquisition and processing, data analysis, and preparation of manuscripts for publication in peer-reviewed journals. Active participation in national and international conferences is also expected.

Requirements include an excellent master's degree in bioinformatics, epidemiology, biomedical sciences, or related disciplines, demonstrable interest in quantitative research, and strong analytical skills. First experience with analysing high-throughput sequencing data (e.g., RNASeq) and performing Quality Control for such data is a plus, as is experience in epidemiological research or large-scale clinical studies. First programming experience (preferably in R) is also required. Excellent analytical and problem-solving skills, proficiency in spoken and written English, and the ability to work as part of an interdisciplinary and international team are essential.

We offer an interesting and challenging position on the forefront of health research, work in a highly interdisciplinary and international team to address pressing health issues related to aging, excellent scientific infrastructure with state-of-the-art research and computational facilities, active encouragement and support of our employees' individual development, and employment, payment, and social benefits in line with the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst).

The PhD position will be integrated into the Bonn International Graduate School of Clinical and Population Science and further training in epidemiological, statistical, and computational methods will be provided as needed. The position is initially limited to three years with the possibility of extension.



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