Postdoctoral Researcher

vor 2 Wochen

Berlin, Berlin, Deutschland MDC Vollzeit
Job Title: Postdoctoral Researcher

About the Position

We are seeking a highly motivated Postdoctoral Researcher to join our team at the Max Delbrück Center (MDC) in Berlin, Germany. The successful candidate will contribute to a shared grant between Manuel Irimia (CRG-UPF, Barcelona) and Nikolaus Rajewsky (BIMSB-MDC) and engage in dynamic and highly multidisciplinary collaborations with several groups in Berlin as well as with colleagues in the Irimia lab in Barcelona, Spain.

Research Focus

The candidate will develop and optimize computational tools to identify and quantify alternative splicing using data generated by different methods of single-cell transcriptomics (both short and long reads). By studying different experimental systems, we aim to answer questions such as:

  • How extensive is alternative splicing heterogeneity among cells of the same type?
  • How does this heterogeneity compare and associate with that at the gene expression level?
  • How is alternative splicing mis-regulated in individual cell types in different disease contexts?
  • How much do alternative splicing profiles contribute to define cell type identity?
  • How are microexons and other cell type specific exons regulated during differentiation?
  • How conserved is alternative splicing at the cell type level, and can we identify novel isoforms specific to rare cell types?

Requirements

The ideal candidate should have a PhD in the fields of Bioinformatics, Functional Genomics and/or Molecular Biology. Previous experience in computational transcriptomic analyses of single-cell RNA-seq and/or of alternative splicing is highly desirable. Expertise in neurobiology and evolutionary genomics is not essential, but will be a plus.

We Offer

International working environment with communication in English and German

Interesting career opportunities and a range of opportunities for further qualification and training

Compatibility of family and career certified by the workandfamily audit ("berufundfamilie audit")

Support for "New Berliners" through the MDC Welcome & Family Office

On-campus health and fitness center

You also benefit from:

  • A remuneration in accordance with the collective agreement for the federal public service (TVöD-Bund), including additional company pension schemes
  • Opportunities to perform research visits at the Irimia lab at the CRG (Barcelona, Spain)
  • Flexible working hours and childcare support
  • Subsidy for the job ticket
  • Additional health benefits such as flu vaccination, eye test, ergonomics advice at the workplace
  • A modern research building in the center of Berlin
  • The possibility of mobile working

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