PhD Position in Translational Biochemistry/Biophysics
vor 3 Wochen
Our primary goal is to unravel the molecular mechanisms underlying pediatric neurogenetic disorders and muscular dystrophies. By understanding these mechanisms at a fundamental level, we aim to pave the way for personalized treatment strategies.
Methodological ExcellenceOur approach involves the expression of recombinant mutant proteins, followed by rigorous biochemical and biophysical characterization. This process is crucial for understanding disease mechanisms at the molecular level. Additionally, we incorporate advanced in-silico methods, including molecular modeling, to complement our experimental work.
Transdisciplinary ApproachOur research ethos is firmly rooted in transdisciplinarity. We seek to integrate diverse scientific perspectives to develop and refine personalized treatment approaches. This includes the exploration of suitable chemical chaperones and other novel therapeutic avenues.
Join Our Dynamic Research GroupAs a Ph.D. student in our team, you will be at the forefront of scientific innovation, working alongside leading experts in the field. You will have the opportunity to contribute to research that has the potential to transform the lives of those affected by these challenging disorders.
You will engage in cutting-edge research, develop your expertise in advanced scientific techniques, and collaborate with a network of renowned scientists and researchers. Your work will be instrumental in advancing our understanding and treatment of pediatric neurogenetic disorders and muscular dystrophies.
You will be part of a graduate school for PhD Students within the University Ulm.
Your Responsibilities- Proteomics techniques for biomarker discovery and understanding of pathological pathways
- Expression and Characterization of recombinant wild-type and mutant proteins by biophysical methods
- Determination of the exact biochemical function of these proteins and screening for chemical chaperones stabilizing mutant proteins
- Analysing multi-omics data including genomic sequences aiming to discover novel disease causing mutations
- Working in collaboration with an international team under supervision and leadership of the PI
- Publishing impactful original research papers
The jobs (65%) is currently for 2 years but will be extended if the candidate is successful. Very good scientific environment, broad repertoire of methods, supportive supervision and a friendly group. Short-term visits to other labs in Germany and abroad.
The Board of Directors of the University Hospital Ulm places strong emphasis on gender equality and seeks to increase the proportional representation of women in this field. Thus, applications from female scientists are welcome; suitably qualified women will be given preferential consideration unless other candidates clearly demonstrate superior qualifications.
We also welcome applications from disabled candidates, who will also be given preferential consideration over other applicants with comparable qualifications.
Minimum Qualifications- Masters degree or equivalent in natural sciences
- A strong interest in protein biochemistry or protein biophysics and/or glycobiology research
- Or a strong interest computational biology including protein modeling and next generation sequencing data analysis
- A solid background in molecular biology is desired
- Candidates with computational and programming skills are preferred
- Candidates coming from chemistry and physics background also are encouraged to apply
- Candidates should be creative and capable of developing a competitive research project while working in collaboration with postdocs and other team members under the supervision of the team leader
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