High-Throughput Microchip NMR Engineer
vor 1 Monat
Pharmaceutical research is increasingly reliant on advanced in-vitro models (AIM) based on sophisticated cell cultures and aggregates for pre-clinical testing. AIM offer a potentially more accurate alternative to animal models, driven by the need to reduce animal testing. However, gaining useful information from AIM is a challenge, as analytical techniques must be highly informative while keeping cells alive and functional. Nuclear Magnetic Resonance (NMR) spectroscopy provides detailed, non-invasive, real-time insights into AIM life processes but is currently limited to single sample observation. This project aims to efficiently analyse multiple samples to enable high-throughput operation.
Project Objectives- Develop and produce a microfluidic insert that integrates with commonly used biological culturing platforms.
- Design and build a prototype of the insert injector system for integration into an NMR spectrometer.
- Conduct a proof-of-concept study to showcase the high-throughput capabilities of the system within an NMR spectrometer environment.
The successful project is expected to lead to at least one publication in an internationally peer-reviewed journal.
RequirementsYou are an ambitious mechanical engineer passionate about product design. You should possess proficiency in 3D modeling and practical expertise in programming microcontrollers.
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High-Throughput Microchip NMR Engineer
vor 2 Wochen
Karlsruhe, Baden-Württemberg, Deutschland Karlsruher Institut für Technologie VollzeitProject OverviewThe Karlsruher Institut für Technologie is seeking a skilled mechanical engineer to develop and implement a multisample analysis capability for Advanced In-Vitro Models (AIM) by Nuclear Magnetic Resonance (NMR) spectroscopy.This project aims to efficiently analyze multiple samples to enable high-throughput operation, allowing for...
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High-Throughput Microchip NMR Engineer
vor 2 Wochen
Karlsruhe, Baden-Württemberg, Deutschland Karlsruher Institut für Technologie VollzeitProject OverviewThe Karlsruher Institut für Technologie is seeking a skilled mechanical engineer to develop and implement a multisample analysis capability for Advanced In-Vitro Models (AIM) by Nuclear Magnetic Resonance (NMR) spectroscopy.The successful candidate will design and build a prototype of the insert injector system for integration into an NMR...
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High-Throughput Microchip NMR Researcher
vor 4 Wochen
Karlsruhe, Baden-Württemberg, Deutschland Karlsruher Institut für Technologie VollzeitJob DescriptionThe Karlsruher Institut für Technologie is seeking a highly skilled and ambitious mechanical engineer to develop and implement a multisample analysis capability for Advanced In-Vitro Models (AIM) by Nuclear Magnetic Resonance (NMR) spectroscopy.The successful candidate will design and build a prototype of the microfluidic insert injector...
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High-Throughput Microchip NMR Researcher
vor 4 Wochen
Karlsruhe, Baden-Württemberg, Deutschland Karlsruher Institut für Technologie VollzeitJob DescriptionThe Karlsruher Institut für Technologie is seeking a highly skilled and ambitious mechanical engineer to develop and implement a multisample analysis capability for Advanced In-Vitro Models (AIM) by Nuclear Magnetic Resonance (NMR) spectroscopy.The successful candidate will design and build a prototype of the microfluidic insert injector...
-
High-Throughput Microchip NMR Engineer
vor 1 Monat
Karlsruhe, Baden-Württemberg, Deutschland Karlsruher Institut für Technologie VollzeitJob DescriptionPharmaceutical research is increasingly reliant on advanced in-vitro models (AIM) based on sophisticated cell cultures and aggregates for pre-clinical testing. AIM offer a more accurate alternative to animal models, driven by the need to reduce animal testing. However, gaining useful information from AIM is challenging, as analytical...
-
High-Throughput Microchip NMR Engineer
vor 1 Monat
Karlsruhe, Baden-Württemberg, Deutschland Karlsruher Institut für Technologie VollzeitJob DescriptionPharmaceutical research is increasingly reliant on advanced in-vitro models (AIM) based on sophisticated cell cultures and aggregates for pre-clinical testing. AIM offer a more accurate alternative to animal models, driven by the need to reduce animal testing. However, gaining useful information from AIM is challenging, as analytical...
-
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