Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE) is a premier institution dedicated to pioneering research in the field of neurodegenerative diseases. With a team of approximately 1,200 professionals across multiple locations in Germany, we are committed to advancing our understanding of conditions such as Alzheimer's, Parkinson's, and ALS.

We invite you to join our team and contribute to our ambitious research objectives.

We are looking for a passionate and driven PhD candidate to engage in research at the intersection of neuroscience and immunology.

The successful candidate will join the 'Translational Neuroimmunology' research group, directed by Dr. Róisín McManus, which operates at the DZNE in Bonn and collaborates with the Institute of Innate Immunity at the University Hospital Bonn, as well as the ImmunoSensation2 Cluster of Excellence.

Our research aims to elucidate the role of microglia-mediated neuroinflammation in the progression of Alzheimer's disease. We specifically investigate how immune signaling and metabolic alterations influence microglial function and disease outcomes.

Recent findings indicate that a western diet can induce lipid alterations that activate microglia, leading to neuroinflammation. As a PhD candidate, your research will focus on identifying the innate immune pathways that drive these neuroinflammatory processes, thereby contributing to our understanding of Alzheimer's disease.

This role will involve conducting cell culture experiments with murine and human cells, performing immune activation assays, and utilizing advanced laboratory techniques, including metabolic assays, flow cytometry, fluorescence imaging, RNA sequencing, and various biochemical methods such as western blotting and quantification assays. You will assess the comprehensive impact of a western diet on microglial activity through in vivo, ex vivo, and in vitro approaches, integrating dietary interventions, pharmacological treatments, and genetic modifications.

• A Master's degree in immunology, neuroscience, biology, or a related field.
• Experience in experimental animal research and familiarity with immunology, neuroscience, or cellular metabolism is highly advantageous.
• FELASA accreditation is a significant asset.
• Practical experience in cell culture (e.g., murine microglia or human iPSC-derived microglia) and biochemical techniques (protein assays, western blotting, PCR); knowledge of immunohistochemistry or flow cytometry is a plus.
• Proficiency in English for effective communication, writing, and presentation of scientific findings.
• A strong enthusiasm for exploring and implementing innovative techniques.
• A willingness to collaborate within a diverse and interdisciplinary team of international researchers.

• Innovation and International Collaboration - Access to modern laboratory facilities, advanced equipment, and opportunities for international exchange with colleagues from diverse backgrounds.
• Work-Life Balance - Flexible working hours, mobile working options, and generous vacation policies.
• Family-Friendly Environment - Supportive initiatives for work-life integration, including parent-child offices and daycare partnerships.
• Health and Wellbeing - Comprehensive health programs in collaboration with Sozialwerk.Bund.
• Professional Development - Tailored training programs and annual development meetings to support your career growth.
• Competitive Compensation - Salary and benefits in accordance with TVöD-Bund, including special payments and pension schemes.
• Comprehensive Onboarding - A structured onboarding process to ensure a smooth transition into your new role.
• Supportive Work Environment - A pleasant campus setting with access to amenities and public transport.
• Opportunities for Knowledge Sharing - Regular seminars on immunology, neuroscience, and related biomedical topics featuring national and international speakers.
• Possibility to present research findings at prestigious conferences.
• This position is initially limited in duration.