Postdoctoral Fellow
vor 3 Monaten
Postdoctoral Fellowships
EMBL Heidelberg
EMBL is Europe’s life sciences laboratory - an intergovernmental organisation with more than 110 independent research groups and service teams covering the spectrum of molecular biology. It operates across six sites in Heidelberg (headquarters), Barcelona, Cambridge, Grenoble, Hamburg and Rome. Our mission is to perform basic research in molecular biology; train scientists, students and visitors at all levels; offer vital services to scientists in the public and private sectors within the member states; develop new instruments and methods; and engage actively in technology transfer.
**About the groups**:
The Krebs group at EMBL studies the mechanisms used by Transcription Factors to interpret the regulatory genetic information. We contributed to the field’s understanding of cooperativity mechanisms (Sönmezer C, _et al_, 2021), the influence of DNA methylation (Kreibich et al, 2023) and nuclear context on the function of enhancers. Our approach combines development of new genomics strategies such as single molecule footprinting and high-throughput perturbation systems (Krebs A, _et al_, eLife 2019) to understand how Transcription Factors control cell identity.
The Gunawardena lab develops mathematical theory and models to describe biological systems with a focus on gene regulation. We developed the first methods for assessing the role of energy expenditure in eukaryotic gene regulation (Estrada et a, 2016; Biddle et al, 2019) and introduced the concept of a Hopfield barrier, that demarcates the information processing that is achievable at thermodynamic equilibrium (Martinez-Corral et al, 2024). These results rely on a graph-based approach to Markov processes called the linear framework (Nam et al, 2022) that will provide a foundation for this project.
Your role
**About the project**:
**Closing date**: 31 October 2024
Contract duration: 2 years
Grading: Stipend Year 1
Reference number: HD02717
You have
A PhD or equivalent qualification in biology, mathematics or physics with a strong expertise in mathematical modelling, especially in biological contexts. You are interested in mechanisms of genome regulation, enthusiastic for large scale quantitative experimental biology. You are excited by biological discoveries, you are interested in interdisciplinary science, and you enjoy collaborative work.
Why join us
EMBL is curiosity-driven, community-oriented and international. As an inclusive, equal opportunity employer, we believe that diversity enables us to collaborate more effectively and be innovative in our approaches. We are, therefore, committed to creating an inclusive and flexible culture - one where everyone can realise their full potential and make a positive contribution to our organisation.
EMBL offers attractive conditions and benefits appropriate to an international research organisation with a very collegial and family-friendly working environment. Competitive salary and social security benefits, financial support for relocation, a relaxed culture, professional development, an on-site nursery, canteen and other staff facilities make EMBL a great place to work.
What else you need to know
We are Europe’s research laboratory for the life sciences - an intergovernmental organisation performing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary laboratory with more than 1900 employees from many nations, operating across six sites, in Heidelberg (HQ), Barcelona, Hinxton near Cambridge, Hamburg, Grenoble and Rome.
Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research. The working language of the institute is English.
EMBL is a signatory of DORA. Find out how we implement best practices in research assessment in our recruitment processes here.
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