Postdoctoral Position in Neurobiology
vor 5 Monaten
At the Center for Organismal Studies (COS) the following position is to be filled
(full time with 39,5 h/week):
**Postdoctoral Position in Neurobiology (f/m/d)**
Project:
**Neuronal and biophysical mechanisms of light-responsive behaviours mediated by simple eyes in aquatic larvae**
Complex animal eyes evolved many times independently from simpler forms. As already suggested by Darwin, the path to vision may have led from non-directional to directional light sensing and then to low-resolution spatial vision. Simple eyes in extant animals show a remarkable diversity of form and function and may hold the key to the origin of eyes and vision. We do not know why this diversity evolved when the organisms all respond to the same physical cue.
In our ERC-funded project PROTOEYE we study the diversity of simple non-visual and visual eyes and map the phase space of light-guided behaviours across animals. This will inform general principles of sensory system evolution and our understanding of the origin and evolution of eyes and visual circuits. The project builds on our long-term expertise in neural circuits and mechanistic photo-biology. We study a range of aquatic invertebrates with distinct behavioural strategies, unified by the presence of simple eyes and non-visual photoreceptors. Instead of looking at eyes in isolation, we investigate light responses from a whole-organism perspective focusing on circuits, behaviour and the biophysics of motion. In order to obtain entire neuronal circuits driving photic behaviours, we use whole-body serial electron microscopy and connectomics. With laser ablation, we explore strategies of light-seeking or light-avoidance behaviours. In high-throughput behavioural assays we test navigation strategies and sensitivities to different wavelengths. With high-speed imaging and flow tracing, we investigate how animal movement is shaped by light.
**Your tasks**:
- Development of high-speed imaging assays for ciliary dynamics and photic behaviours in small aquatic ciliated larvae
- Volume EM analysis of marine larvae, including sample preparation, sectioning, imaging and image analysis
- Development of expansion microscopy protocols for ciliated larvae followed by fluorescent volume imaging
- Data analysis, data plotting, figure composition and writing of manuscripts in a version-controlled workflow (e.g. as an R project with GitLab integration)
- In-depth analysis and following of the relevant literature
**Your profile**:
- PhD in Neurobiology, Behavioural Science, Biophysics, Developmental and Cell Biology or related disciplines
- Interest in imaging techniques, non-conventional animal models, curiosity-driven research
- Experience in organismal biology, systems thinking and handling of animal model organisms
- Experience in data analysis or programming in R/Python
- Good English language skills
- Commitment to open science
The position is generally divisible. Remuneration is based on TV-L (E 13). The position is limited to
December 31, 2026.
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