Postdoc Position

Das Universitätsklinikum Bonn
- Wir vereinigen Exzellenz in Forschung, Lehre und Krankenversorgung sowie Wirtschaftlichkeit.Im UKB werden pro Jahr etwa 500.000 Patient*innen betreut, es sind ca. 9.000 Mitarbeiter*innen beschäftigt und die Bilanzsumme beträgt 1,6 Mrd. Euro. Neben den über 3.300 Medizin
- und Zahnmedizin-Studierenden werden pro Jahr weitere 585 Personen in zahlreichen Gesundheitsberufen ausgebildet. Das UKB steht im Wissenschafts-Ranking sowie in der Focus-Klinikliste auf Platz 1 unter den Universitätsklinika (UK) in NRW und weist den dritthöchsten Case Mix Index (Fallschweregrad) in Deutschland auf.- Vollzeit- ab sofortThe University Hospital Bonn (UKB) is a maximum care hospital with more than 1,300 beds. Our more than 9,000 employees take on tasks in research, teaching and patient care as well as in public health at the highest level. In the science ranking (LOMV) and in the economic result, the UKB is number 1 of the university hospitals in NRW and in 2021 had the third highest case mix index of the university hospitals in Germany.

**P**ostdoc** position - **Mucosal Immunology and microbiota research **(M/F/**o**)**

Available immediately for two years due a project with the possibility of extension.

**A postdoc position is** available **to study the **intestinal** **antibody response to the microbiota in inflammatory bowel disease**. **We will functionally study the antibody responses to the intestinal microbiota and the antibody function down to the single B cell receptor specificity level. Therefore, we will employ single B cell receptor immunoglobulin gene sequencing, sequence-guided gene synthesis, monoclonal antibody production, antibody binding assays, germ-free, and gnotobiotic mouse models, in vivo bacterial transcriptomics, and host omics analysis. **Our aim is to obtain a detailed mechanistic understanding of a subset of human antibodies in ulcerative colitis**:

- For related previous work see the following links:_

**We offer**:

- **Excellent working conditions and competitive remuneration**.**:

- Dynamic, multidisciplinary, and international setting with strong immunology focus.
- Possibility to perform part of the work in Osaka, Japan up to 6 months.
- Participation in national and international conferences.
- Living in an active university city with access to many cultural possibilities.
- Salary according to the German TV-L13 and additional benefits such as a pension plan.
- Possibility to co-supervise undergraduate students and technicians
- Close supervision in regular meetings
- State of the art equipment and scientific methods
- Core facilities to support your research

**Your profile**:

- PhD in immunology or closely related field
- Excellent communication skills, because the project is a collaborative effort
- Excellent study or research performance
- Ability to perform part of the work abroad in Osaka, Japan in the laboratory of our collaboration partner
- You possess high scientific integrity
- Profound knowledge and experience in flow cytometry
- **The project requires animal experimentation (mice), and previous exposure to in vivo work would be advantageous but is not a requirement.**:

- Ability to work precisely in the laboratory environment
- Interest to learn germ-free and gnotobiotic animal handling techniques
- Experience and/or interest to perform Ig gene repertoire data analysis using programming languages (mostly R)

We are committed to diversity and equal opportunities. Our goal is to increase the proportion of women in areas where women are underrepresented and to particularly promote their careers. We therefore urge relevantly qualified women to apply. Applications are treated in accordance with the State Equal Opportunities Act. Applications from suitable people with proven severe disabilities and those of equal status are particularly welcome.

**How to apply**:
**Application documents include a motivation letter, detailed CV (including the names of former mentors and supervisors), publication list (if applicable), relevant transcripts, and recommendation letters and/or contact information of at least two references.**

**We are strongly committed to promote equal opportunities independent of gender, ethnicity, age, **_nationality, religion, disability_, etc.. Therefore, a_pplications will be handled in accordance with the State Equality Act.
- Additional information:_

**Wir setzen uns für Diversität und Chancengleichheit ein.**:
Unser Ziel ist es, den Anteil von Frauen in Bereichen, in denen Frauen unterrepräsentiert sind, zu erhöhen und deren Karrieren besonders zu fördern. Wir fordern deshalb einschlägig qualifizierte Frauen nachdrücklich zur Bewerbung auf. Bewerbungen werden in Übereinstimmung mit dem Landesgleichstellungsgesetz behandelt. Die Bewerbung geeigneter Menschen mit nachgewiesener Schwerbehinderung und diesen gleichgestellten Personen ist besonders willkommen.