Phd Position in Experimental Translational Oncology

vor 2 Wochen

Nuernberg, Deutschland Helmholtz Zentrum München Vollzeit

102407

Full time

Neuherberg near Munich

Home Office Options

We are Helmholtz Munich. In a rapidly changing world, we discover breakthrough solutions for better health.

Our research is focused within the areas of metabolic health/diabetes, environmental health, molecular targets and therapies, cell programming and repair, bioengineering, and computational health. We particularly excel in the fields of basic research, bioengineering, artificial intelligence, and technological development.

Through this research, we build the foundations for medical innovation. Together with our partners, we seek to accelerate the transfer of our research, so that laboratory ideas can reach society and improve people’s quality of life at the fastest rate possible.

This is what drives us. Why not join us and make a difference?

Precision therapy of cancers requires a stratification of patients and an identification of therapeutic targets by integration of multi-level omics data, metabolic data and clinical data from oncological cohorts. The grand challenges in clinical oncology are therapy failure and the occurrence of tumor relapses after radiotherapy. Main causes of therapy failures are tumor heterogeneity, tumor immune escape, tumor metabolic processes and tumor-intrinsic signaling that lead to therapeutic resistance. The personalized treatment of cancer requires finer grained stratification of patients for which we develop stratification markers and models predicting local and distant tumor control after radiotherapy. At the same time, we use these insights to identify novel therapeutic targets and combination therapies.

Elizabeth Blackburn - Molecular Biologist "I didn't want to just know names of things. I remember really wanting to know how it all worked."

Your tasks
- Establishment and analysis of clinical cancer patient cohorts and cell culture models to characterize senescence-associated mechanisms of therapeutic resistance and to identify prognostic markers
- Generation of high-dimensional omics data sets at different molecular levels from cancer patient cohorts and model systems
- Interdisciplinary collaboration with biologists, bioinformaticians, mathematicians, statisticians and clinicians
- Presentation of research findings at national and international scientific conferences
- Contribution to the preparation of scientific manuscripts for publication

**Profile**:

- Master’s degree in life sciences (biology, biochemistry, biomedicine, molecular medicine, etc.)
- Practical laboratory skills in molecular biology, genetics or biochemistry
- Enthusiasm and strong motivation to work in an interdisciplinary team in translational oncology
- Exceptional teamwork and collaboration skills
- Proficiency in written and spoken English, German language skills are advantageous
- Interest and/or experience in programming and statistics

**Benefits**:
Since 2005, we hold the TOTAL E-QUALITY award for exemplary action in the sense of an equal-opportunity organizational culture.

Helmholtz Munich is actively committed to diversity and inclusion in practice and is sustainably committed to equality.

The Diversity Charter has set itself the goal of promoting diversity in the world of work. By signing the charter, we commit ourselves to create an appreciative working environment for all employees.

This position provides the opportunity for you to build specialist knowledge whilst developing key professional experience, both of which will help you to make strides in your scientific career.

Remuneration and social security benefits are based on the German Collective Wage Agreement for Public-Sector Employees at Federal Level (EG 13 50% TV EntgO Bund). In addition, there is also the possibility of receiving an allowance if the applicable conditions are met. The position has an (initial) fixed term of three years but may be extended under certain circumstances.

Interested in applying?

We are Helmholtz Munich.

How we promote your career?

Helmholtz Munich
Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
Research Unit Translational Metabolic Oncology
Ingolstädter Landstraße 1
85764 Oberschleißheim

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