![Helmholtz Zentrum München](https://media.trabajo.org/img/noimg.jpg)
Master Thesis
vor 4 Wochen
A heterozygous mutation in the PURA gene can cause the neurodevelopmental disorder PURA Syndrome. First described in 2014, today there are over 478 diagnosed cases worldwide and the number is constantly increasing. The PURA protein is expressed in every human tissue. Apart from already published detailed structural data, very little is known about the underlying mechanisms that lead to the severe symptoms of PURA Syndrome including neurodevelopmental delay, intellectual disability, hypotonia, and epilepsy.
We at the Institute of Structural Biology at the Helmholtz Center Munich study the structure and cellular function of the PURA protein. Thus, we are trying to understand the molecular consequences of a PURA deficiency in PURA Syndrome patients. We use genetically modified immortalized cell lines and patient specific induced pluripotent stem cells (iPSCs). High-throughput techniques in these cells already gave us first ideas about PURA’s interactome and in which pathways PURA may play a role. These data needs further validation to identify specific molecular mechanisms that cause the severe disorder previously described. Ultimately, we want to provide information that can lead to the development of treatment strategies for PURA Syndrome patients.
Interested? Join us on this crucial and challenging task for your master thesis or contact us if you want to be part of this as an intern. What to expect?
- Cell culture (HeLa-cells, human neural stem cells, iPSCs, patient fibroblasts)
- Neuronal differentiation of iPSCs
- Molecular cloning
- Real-time qPCR and western blotting
- Immunofluorescence experiments
- Working with different CRISPR/Cas9 systems
- Proteome interaction studies
- Interpreting and evaluating results
- Independent lab work
Contact: sabrina.bacher(at)helmholtz-muenchen.de (direct supervisor)
Art der Stelle: Praktikum
Vertragsdauer: 6 Monate
Arbeitszeiten:
- Montag bis Freitag
Arbeitsort: Ein Arbeitsort
-
Master thesis in bee conservation
vor 1 Woche
Munich, Deutschland technical university of munich VollzeitMaster thesis in bee conservation (remote) 03.04., Studentische Hilfskräfte, Praktikantenstellen, Studienarbeiten Are you looking for a thesis in biology, environmental sciences or related? Do you want to work on data between ecology and social sciences? We have a project for a master thesis doing literature search and quantitative and qualitative...
-
Master thesis in bee conservation
vor 1 Woche
Munich, Deutschland Technical University of Munich VollzeitMaster thesis in bee conservation (remote) 03.04., Studentische Hilfskräfte, Praktikantenstellen, Studienarbeiten Are you looking for a thesis in biology, environmental sciences or related? Do you want to work on data between ecology and social sciences? We have a project for a master thesis doing literature search and quantitative and...
-
Master Thesis Student
vor 4 Wochen
Munich, Deutschland Arrow Electronics, Inc. Vollzeit**Position**: Master Thesis Student Make familiar with ARROWs processes and abilities in Engineering and Sales **Location**: DE-Munich, Germany (Elsenheimerstraße) 38.2 Hrs **Time Type**: Full time **Job Category**: Business Support
-
Munich, Deutschland Technische Universität München VollzeitMaster thesis on plant-pollinator networks in the Alps We have a project offer for a master thesis in environmental sciences or related disciplines, for investigating plant-pollinator networks in grassland ecosystems of the Berchtesgaden National Park Are you looking for a master thesis in biology, environmental sciences or related? Are you interested in...
-
Master thesis in bee conservation
vor 2 Wochen
Munich, Bayern, Deutschland Technical University of Munich VollzeitMaster thesis in bee conservation (remote) 03.04., Studentische Hilfskräfte, Praktikantenstellen, Studienarbeiten
-
Munich, Deutschland Technical University of Munich VollzeitMaster thesis in plant-insect interactions in the Alps 08.04., Studentische Hilfskräfte, Praktikantenstellen, Studienarbeiten Master thesis on plant-pollinator networks in the Alps We have a project offer for a master thesis in environmental sciences or related disciplines, for investigating plant-pollinator networks in grassland ecosystems...
-
Master thesis in bee conservation
vor 1 Monat
Munich, Deutschland Technical University of Munich VollzeitMaster thesis in bee conservation (remote) 03.04., Studentische Hilfskräfte, Praktikantenstellen, Studienarbeiten
-
Master Thesis Cross-talk Quantification in
vor 3 Wochen
Munich, Deutschland BMW Vollzeit**SOME IT WORKS. SOME CHANGES WHAT'S POSSIBLE.** **SHARE YOUR PASSION.** More than 90% of automotive innovations are based on electronics and software. That's why creative freedom and lateral thinking are so important in the pursuit of truly novel solutions. And that’s why our experts will treat you as part of the team from day one, encourage you to...
-
Bachelor or Master Thesis in Phage Therapy
vor 1 Woche
Munich, Deutschland Helmholtz Zentrum München Vollzeit: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world. At our institute you will find a scientifically stimulating international environment. Together with renowned scientists and supported by an excellent infrastructure you will have the opportunity to make an important...
-
Master Thesis
vor 1 Woche
Munich, Bayern, Deutschland Airbus VollzeitJob Description: In order to support the Communication Technologies at Airbus Corporate Research and Technology, Airbus Defence and Space is looking for a Master Thesis / Internship on Quantum Communication (d/f/m) You are looking for a master thesis / internship and want to get to know the work of a scientist at Airbus ? Then apply now We look forward to...
-
Master Thesis Innovative Analysis Methods for
vor 3 Wochen
Munich, Deutschland BMW Vollzeit**THE FUTURE WILL NEVER SIMPLY WORK IN THEORY.** **SHARE YOUR PASSION.** World-leading technologies don’t make it into a BMW until they’ve undergone one of the most challenging journeys imaginable. It takes dynamic teams with outstanding technical skills to take them from the drawing board to the road. That’s why our experts will treat you as part of...
-
Master Thesis
vor 1 Woche
Munich, Bayern, Deutschland Airbus VollzeitJob Description: In order to support Network Scanners, Airbus Defence and Space is looking for a Master Thesis / Internship (d/f/m) on 5G Positioning Receivers You are looking for a master thesis / internship and want to get to know the work of an innovation engineer at Airbus? Then apply now We look forward to you supporting us in the Future Navigation...
-
Master Thesis
vor 4 Wochen
Munich, Deutschland Reactive Robotics GmbH Vollzeit**About us** Reactive Robotics is the world’s first company to introduce robotics to intensive care units. We support nurses and therapists in providing robot-assisted therapy to their patients. Our company is growing fast and, by working with us, you will gain responsibilities quickly. Our diverse team is open-minded, highly-motivated, and...
-
Bachelor/master Thesis: Optimization of Mouse Whole
vor 3 Wochen
Munich, Deutschland Helmholtz Zentrum München Vollzeit: Discover personalized medical solutions for environmentally triggered diseases to promote a healthier society in a rapidly changing world. We are seeking a highly motivated and talented student (f/m/x) with biological knowledge. You will work in an innovative, well-equipped and scientifically stimulating surrounding, where you will combine theory and...
-
Internship And/or Master Thesis Within The Overall
vor 3 Wochen
Munich, Deutschland Airbus VollzeitA vacancy for an Internship and/or Master Thesis within the Overall Structural & Aeromechanics squad (M/F/d) in the Urban Air Mobility team has arisen in Donauwörth. **Our Purpose, Our Team and Our Ambition** Airbus Urban Mobility (AUM) aims at laying the foundation for more efficient and sustainable city travel. To co-create an entire industry from...
-
Master Thesis Hw-sw-co-design
vor 2 Wochen
Munich, Deutschland BMW Vollzeit**SOME IT WORKS. SOME CHANGES WHAT'S POSSIBLE.** **SHARE YOUR PASSION.** More than 90% of automotive innovations are based on electronics and software. That's why creative freedom and lateral thinking are so important in the pursuit of truly novel solutions. And that’s why our experts will treat you as part of the team from day one, encourage you to...
-
Internship/ Master Thesis
vor 2 Wochen
Munich, Bayern, Deutschland Linde GmbH, Corporate Office VollzeitLinde GmbH, Corporate OfficeInternship/ Master Thesis - Automated data processing for Gas Atomization (M/F/d)Unterschleißheim, Germany | req16558What you will enjoy doing The Linde Technology (LT) department for Additive Manufacturing and Powder Metals seeks a dedicated student (mandatory Internship/Thesis) to support the R&D team in Unterschleißheim,...
-
Master Thesis: Characterization of Cmos Based
vor 2 Wochen
Munich, Bayern, Deutschland Microsystems and Solid State Technologies VollzeitFraunhofer EMFT conducts cutting-edge applied research on sensors and actuators for people and the environment. The about 150 employees in the three locations in Munich, Oberpfaffenhofen and Regensburg possess impressive long-term experience and wide-ranging know-how in the fields of microelectronics and microsystem technology. The technology offering of the...
-
Master Thesis
vor 2 Monaten
Munich, Deutschland Siemens Vollzeit**Mode of Employment**: Limited **Use your knowledge as a springboard.** Do you like the sound of finding the smartest solution side by side with professionals and experts? If so, complete your bachelor’s or master’s thesis with us. We can help you to combine knowledge, discover connections, and formulate ideas. When you join our team, you will gain an...
-
Master Thesis
vor 3 Monaten
Munich, Deutschland NXP Semiconductors VollzeitThe final thesis should be a comprehensive analysis of the safety concepts and a comparison between Automotive, Industrial and Medical Functional Safety. The specific tasks: - Support a student during his PhD thesis on similar topic - Compare with Automotive and Industrial safety concepts with deep technical understanding (cooperating with all NXP Product...