Phd Student

vor 4 Wochen

Dresden, Deutschland Helmholtz-Zentrum Dresden-Rossendorf e.V. Vollzeit

**Helmholtz-Zentrum Dresden-Rossendorf e.V.**:
With cutting-edge research in the fields of ENERGY, HEALTH and MATTER, around 1,500 employees from more than 70 nations at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) are committed to mastering the great challenges facing society today.

At the Institute of Radiopharmaceutical Cancer Research scientists (f/m/d) from the fields of physics, chemistry, biology, pharmacy, immunology, medicine and IT develop innovative radiopharmaceuticals and novel tools for functional characterization, improved imaging and personalized treatment of tumors.
- The Department of Radioimmunology is looking for a
- PhD Student (f/m/d) Pre-clinical development and validation of Adapter-RevCAR‐T-cell-system for immunotherapy of melanoma

**Working field**:

- Generation and characterization of RevCAR-expressing human T-cells on a laboratory scale
- Design, generation and characterization of RevCAR targeting molecules (RevTMs) targeting different melanoma markers
- Testing the functionality and efficiency of novel RevTMs in combination with RevCAR-T-cells (RevCAR-T-cell-systems) for monospecific targeting of melanoma cells using 2D and 3D spheroid in vitro models and/or mouse models
- Generation of Dual-RevCAR-T-cells and their functional validation in combination with two different RevTMs (Dual-RevCAR-T-cell approach) for targeting of two melanoma markers (combinatorial melanoma targeting) using 2D and/or 3D spheroid in vitro models and/or mouse models

**Requirements**:

- Completed university studies (Master/Diploma) in the field of Biology, Biotechnology, (Bio-) Chemistry or related field
- Solid knowledge of immunology, protein biochemistry and/or immunotherapy as well as good skills/experience in molecular biology, protein biochemistry, generation of recombinant proteins, working with cell cultures, flow cytometry and in vitro co-culture assays and willingness to work with experimental mice
- Be fascinated by scientific research and innovation, be motivated, enthusiastic and eager to learn, be able to work methodically and accurately, be able to work independently yet also being a team player, have a creative mind and strong problem-solving skills and have a good writing and oral expression
- Fluent written and spoken English skills

**What we offer**:

- A vibrant research community in an open, diverse and international work environment
- Scientific excellence and extensive professional networking opportunities
- A structured PhD program with a comprehensive range of continuing education and networking opportunities - more information about the PhD program at the HZDR can be found at the webpage
- Salary and social benefits in accordance with the collective agreement for the public sector (TVöD-Bund) including 30 days of paid holiday leave, company pension scheme (VBL)
- We support a good work-life balance with the possibility of part-time employment, mobile working and flexible working hours
- Numerous company health management offerings
- Employee discounts with well-known providers via the platform Corporate Benefits
- An employer subsidy for the "Deutschland-Ticket Jobticket"

**How to apply**:

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