Team Tmi

**About BioMed X**

BioMed X is an independent research institute located on the campus of the University of Heidelberg
in Germany. Together with our partners, we identify big biomedical research challenges and provide
creative solutions by combining global crowdsourcing with the local incubation of the world's
brightest early-career research talents. Each highly diverse research team at BioMed X has access to
state-of-the-art research infrastructure and is continuously guided by experienced mentors from
academia and industry. At BioMed X, we combine the best of two worlds - academia and industry
- and enable breakthrough innovation by making biomedical research more efficient, agile, and fun.

**About Translocation of Complex Macromolecules Across the Intestinal**
**Epithelial Barrier (TMI)**

The main objective of the research group TMI, headed by Dr. Kyungbo Kim, is to discover novel
transport mechanisms in the human intestinal tract which could be utilized for oral-systemic delivery
of diverse therapeutic modalities (e.g., peptides, oligonucleotides, and antibodies). Studies will
an organotypic assay system of the intestine. The project's cores are to develop a ligand specific for
a target cell and establish quantitative assessment methods to monitor macromolecular drug
delivery across the intestinal epithelial barrier. Our final goal is to create a novel delivery platform
that can be utilized to develop a new generation of oral immunotherapies to benefit patients.

**The Position**

We have developed ligands for specific human immune cell populations in the human intestine. The
student intern will be involved in ligand-receptor interaction studies using bioluminescence and
colorimetric assays. The assistant will also study how to target a cell of interest and engineer
proteins. Hands-on experience with protein expression and purification is preferred. The ideal
work organization skills and communication skills in English.

**Required skills**:

- Hands-on experience in bacterial protein expression or _in vitro_ translation (preferred)
- Hands-on experience with ELISA, SPR, or IP (preferred)
- Good documentation skills with close attention to detail
- Excellent communication skills in English

**upon incoming documents; hence, please contact us as soon as you decide to apply.