Phd Student in Defining Preterm Infant Gut

vor 2 Monaten

Munich, Deutschland Technische Universität München Vollzeit

starting 01.02.2023 (may also be able to start later)

Job description
Background: Initial colonisation of the gut by pioneer bacterial species is the first key step for host well-being. The process of initial gut microbiota colonisation in preterm babies is radically interrupted due to a variety of factors including mode of delivery and antibiotics. This disturbed colonisation of premature infants appears pivotal to the development of a number of diseases, including necrotising enterocolitis (NEC), which is linked to overgrowth of opportunistic antibiotic resistant pathogens. We critically need new therapies for preventing infections in preterm infants - and bacteriophage, bacterial viruses, nature’s most prevalent bacterial predators, represent an attractive option in the fight against NEC-related pathogens.
The goal of this PhD studentship to uncover the microbiome signatures associated with heathy preterm infants and those that have NEC, through a variety of microbial culturing, next generation sequencing and bioinformatics analysis. Working with the Deng group, phages will be tested for their ability to kill NEC pathogens in a variety of innovative in vitro and in vivo models. Thus, this PhD project represents an exciting and multi-disciplinary environment for breaking new ground in the fight against antibiotic resistant bacteria that cause serious illness in fragile preterm infants.

Required qualification
Salary and duration

Application deadline
Applications will be considered until all positions are filled.

Contact person

Application
Applicants are asked to send one pdf file to the contact person. The file includes
1. cover letter,
2. curriculum vitae,
3. copies of academic degrees and transcripts of records,
4. preferences of projects (optional),
5. contact information for at least one letter of recommendation,
6. list of publications with link for downloading (Do not include your publications in the pdf file).

Data Protection Information:
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