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Phd Student

vor 4 Monaten


Duesseldorf, Deutschland Uniklinik Düsseldorf Vollzeit

At the Department of Pediatric Oncology, Hematology and Clinical Immunology (Head: Prof. Arndt Borkhardt) of the University Clinic Duesseldorf (UKD) at the Heinrich-Heine-University we offer a Ph.D. **student position (f/m/d)**. The position is available from the 1st of February 2023 (TVL-E13, 65%); the position is initially limited to 3 years with the possibility of being extended.

Our research group, led by Prof. Dr. Marc Remke, studies the biology of malignant brain tumors. The research focus is the most common malignant brain tumors in childhood: medulloblastoma, high-grade glioma, and atypical teratoid/rhabdoid tumor (AT/RT). We aim to close the gaps in translational medicine through pharmacogenomic approaches. To this end, we use a high throughput drug screening approach, as well as novel NGS-based technologies, in particular RNA sequencing and single-cell DNA sequencing with an in-lab 10X Genomics system.

**Project description**:
Resistance to chemotherapy is a common cause of treatment failure in cancer patients and a significant problem facing cancer research. The resistance mechanisms to cytotoxic chemotherapeutics and therapies designed to be selective for specific molecular targets share many features, such as alterations in the drug target, activation of pro-survival pathways, and pathway reactivation and ineffective induction of cell death. Therefore, using pathway re

**Requirements**:

- Excellent master’s degree in biology, biochemistry, or related live science disciplines
- Strong background in cell and molecular biology
- Great enthusiasm for oncology research and the ability to work independently
- Excellent command of English and the ability to work in a team

**We offer**:

- A translational project with clinical relevance
- Interesting, versatile workplace
- International, attractive working environment
- Campus with modern state-of-the-art infrastructure
- Access to international research networks
- Flexible working hours
- Comprehensive training and mentoring program through Duesseldorf School of Oncology (DSO)

Art der Stelle: Vollzeit

Gehalt: 2.500,00€ - 3.000,00€ pro Monat

Arbeitszeiten:

- 8-Stunden-Schicht
- Wochenendarbeit möglich

Flexible Sprachanforderungen:

- Keine Deutschkenntnisse erforderlich

Leistungen:

- Betriebliche Weiterbildung

Ausbildung:

- Master (Wünschenswert)

Sprache:

- Englisch (Erforderlich)

Verfügbarkeit für Schichten:

- Spätschicht (Wünschenswert)

Arbeitsort: Ein Arbeitsort

Bewerbungsfrist: 01.03.2023
Voraussichtliches Einstiegsdatum: 03.04.2023