Phd Position

vor 2 Wochen


Stuttgart, Deutschland Universitätsklinikum Tübingen Vollzeit

The Faculty of Medicine is one of the four founding faculties of the Eberhard Karls University of Tübingen. With its non-clinical facilities as well as its research and teaching area corresponding to the organisational units of the University Hospital, it is one of the largest medical training and research institutions in Baden-Württemberg.
The Department of Preclinical Imaging and Radiopharmacy (Director Prof. Bernd Pichler) at the University Hospital of the Eberhard Karls University of Tübingen competes and collaborates on scientific top level in preclinical imaging with international research groups. The research group of Dr. Bézière (Infection & Inflammation) offers a

**PhD position (f/m/d)**:
in the field of Multimodal preclinical imaging of Aspergillus fumigatus invasion and treatment. The position can be filled as soon as possible in part time (65 %) and is initially limited to one year with the possibility of further extension.

**Project description**: Fungal infections are now a major challenge for public health, as the amount of immunocompromised patients is increasing, and more antifungal resistant strains are emerging. In this landscape, the World Health Organization recently published a fungal priority pathogens list to guide research, development and public health action, which highlighted the threat posed by
_Aspergillus fumigatus_. This fungus can invade the airways of immunocompromised hosts, settle in their respiratory systems and further invade other organs if not treated properly. However, proper diagnosis of Aspergillosis is still extremely difficult in these patients as they often require invasive procedures.

In our previous efforts, embedded in an international research network, we have shown the potential of pathogen specific molecular imaging for diagnosis and therapy monitoring of Aspergillosis, from bench to bedside. During these studies, we have also highlighted the need for further continued work on the approach.

In this DFG funded PhD project and in close collaboration with the team of Prof. Gunzer (University of Duisburg-Essen), we want to investigate how modifications of the radiotracer can significantly enhance its diagnosis and therapy monitoring performance using in vitro and in vivo assays, focusing on a multimodal PET/MRI/Fluorescence approach. We fully anticipate this work to translate to the clinics in a short time frame.


**We offer**:

- Collaboration in many-sided environment of a modern university hospital, which, in addition to patient care, also focuses on medical research and teaching- Future-proof workplace and location, attractive remuneration including company pension scheme (VBL) with working time arrangements that are as flexible as possible- Subsidy for public transport ticket and attractive discounts on our platforms for employees- Structured onboarding, possibility to develop professional, social and methodological skills at our academy- Wide range of sports activities available**If you have any questions, please contact**:
**Mr. Dr. Nicolas Bézière**
07071 29-87511

**25.06.2023**
including CV and cover letter under specification of the **index number 2801**.



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