Phd-position - Viral Gene Therapeutics Formulation
vor 7 Monaten
We are looking for a highly motivated PhD student focusing on formulation development of Adeno Associated Virus (AAV) therapeutics in a cross-functional environment and hereby contributing to the establishment of formulation standards for AbbVie’s expanding gene therapy and AAV therapeutics pipeline.
The Biologics-CMC organization is using cutting-edge science and technology, and risk management to develop robust formulations for a broad spectrum of injectable drugs. During the last decade we have extended our focus towards one-time treatments to help patients with severe conditions. The PhD student will support the organization in understanding and implementing formulation approaches for AAV based therapeutics. The main areas of this PhD project include excipient selection and exploration to maximize storage stability, stress test establishment and determination of viral serotype specificities. This includes hands-on laboratory work as well as data analysis and statistical evaluation thereof. The PhD student will also be involved in the establishment of a sound formulation development process for AbbVie’s expanding pipeline of AAV therapeutics. This complex PhD project encompasses collaboration with various internal stakeholders such as NBE analytical, formulation development, bioassay, discovery, and global initiatives as well as external academic partners.
**Key responsibilities include**
- Planning and conducting of complex experiments
- Mammalian cell culture and virus production
- Data analysis and interpretation
- Statistical evaluation of data
- Biochemical/biophysical analysis of AAV (HPLC; MS, DLS, DSF, SEC-MALS, qPCR,)
- Formation of a robust process for formulation development of AAV therapeutics
- Evaluate and establish new state-of-the-art analytical methods
- Use of Quality by Design (QbD) approach
- International communication of research results via articles and oral presentations
- Support of pipeline project activities within Biologics Drug Product Development
- Diploma or master's degree in biochemistry, pharmacy, analytical chemistry, biophysics or equivalent
- Strong self-motivation and resilience
- Ability to navigate in a complex environment with multiple stakeholders
- Structured thinking
- Independent way of working
- Presentation of work progress to a broad audience from different areas via presentations, posters and written reports
- Proficient spoken and written English skills
**Desired add on Qualifications**
- Hands-on experience in one or more of the following analytical methods: HPLC, SEC-MALS, LC/MS, DLS, DSF
- Basic knowledge in virology
- Sound background in protein biochemistry and bioanalytical methods
- Basic understanding in pharmaceutic product development of biotherapeutics including formulation development
This position is for a 3-year assignment.
-
Phd Position in Medical Virology
vor 4 Wochen
Frankfurt am Main, Deutschland Universitätsklinikum Frankfurt Vollzeit(We are targeting applicants of all genders) **Part Time (26h) | limited up to 3 years | Announcement number: 967-2024** The research group of Prof. Sandra Ciesek at the Institute of Medical Virology at Goethe University seeks a highly motivated PhD student to join our research team. The Ciesek lab is interested in understanding host-cell signaling...
-
PhD position in Medical Virology
vor 4 Wochen
Frankfurt am Main, Deutschland Universitätsklinikum Frankfurt Vollzeit"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative...
-
PhD position in Medical Virology
vor 4 Wochen
Frankfurt am Main, Deutschland Universitätsklinikum Frankfurt Vollzeit"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative...
-
PhD position in Medical Virology
vor 4 Wochen
Frankfurt am Main, Deutschland Universitätsklinikum Frankfurt Vollzeit"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative...
-
PhD position in Medical Virology
Vor 4 Tagen
Frankfurt am Main, Deutschland Universitätsklinikum Frankfurt Vollzeit"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative...
-
PhD position in Medical Virology
vor 4 Wochen
Frankfurt am Main, Deutschland Universitätsklinikum Frankfurt Vollzeit"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative...
-
Technical Assistant Upstream Processing
vor 7 Monaten
Frankfurt Am Main, Deutschland Cytiva Vollzeit**Be part of something altogether life-changing!** Working at Cytiva in the Life Sciences industry means being at the forefront of providing new solutions to transform human health. Our incredible customers undertake life-saving activities ranging from fundamental biological research to developing innovative vaccines, new medicines, and cell and gene...
-
frankfurt am main, Deutschland Universitätsklinikum Frankfurt Vollzeit"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative...
-
PhD Position in Virology Research
vor 4 Wochen
Frankfurt am Main, Hessen, Deutschland Universitätsklinikum Frankfurt VollzeitThe Universitätsklinikum Frankfurt is a renowned institution with a rich history dating back to 1914. Our team of approximately 8,500 employees strives for excellence in healthcare, research, and teaching.Job OverviewWe are seeking a highly motivated PhD student to join our interdisciplinary research team at the Institute of Medical Virology. The successful...
-
Medizinischer Fachmann
vor 3 Wochen
Frankfurt am Main, Hessen, Deutschland Merz Therapeutics GmbH VollzeitÜber Merz Therapeutics GmbHAls führendes Pharma-Unternehmen unterstützt Merz Therapeutics Menschen mit Bewegungsstörungen, neurologischen Erkrankungen, Lebererkrankungen und anderen gesundheitlichen Beschwerden bei der Rückgewinnung ihrer Lebensqualität. Nachhaltige Partnerschaften schaffen WerteWir sind stolz darauf, dass wir uns als...
-
Scientist - Cheminformatics (M/F/d)
vor 7 Monaten
Frankfurt am Main, Deutschland Dewpoint Therapeutics VollzeitDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to...
-
Senior Scientist
vor 7 Monaten
Frankfurt am Main, Deutschland Dewpoint Therapeutics VollzeitDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to...
-
Principal Scientist
Vor 6 Tagen
Frankfurt am Main, Deutschland Dewpoint Therapeutics VollzeitDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to...
-
Principal Scientist
vor 7 Monaten
Frankfurt am Main, Deutschland Dewpoint Therapeutics VollzeitDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to...
-
(Senior) Medical Expert
vor 7 Monaten
Frankfurt am Main, Deutschland Merz Therapeutics VollzeitJoin our dynamic team as a **Senior Medical Expert (M/F/d) **for our **New Assets** and play a pivotal role in shaping the future of Merz Therapeutics. Your expertise will drive key Medical Affairs activities, ensuring our product portfolio achieves its full potential globally. **YOUR CONTRIBUTION** - Implement relevant Medical Affairs activities, including...
-
Research Associate
vor 9 Monaten
Frankfurt am Main, Deutschland Dewpoint Therapeutics VollzeitDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to...
-
Senior Research Associate
vor 9 Monaten
Frankfurt am Main, Deutschland Dewpoint Therapeutics VollzeitDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to...
-
Research Associate
Vor 6 Tagen
Frankfurt am Main, Deutschland Dewpoint Therapeutics VollzeitDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to...
-
Intern - Medicinal Chemistry (M/F/d)
Vor 6 Tagen
Frankfurt am Main, Deutschland Dewpoint Therapeutics VollzeitDewpoint Therapeutics translates condensate biology into much-needed medicines. Biomolecular condensates are transforming our understanding of biology, and our highly collaborative team is at the forefront of efforts to harness this shift for drug discovery. Together, we are leveraging a transformative shift in the understanding of cellular biology to...
-
Assistenz (M/w/d) Im Bereich Global Legal &
vor 4 Monaten
Frankfurt am Main, Deutschland Merz Therapeutics Vollzeit**Befristet auf 12 Monate** In der Rolle als **Assistenz (m/w/d) **sind Sie wertvoller Bestandteil unseres globalen Teams Legal, Compliance, Privacy + IP und und unterstützen uns in verschiedenen administrativen Fragestellungen. Ihre Aufgaben umfassen: **IHRE HERAUSFORDERUNGEN** - Unterstützung des Bereichs im operativen Tagesgeschäft sowie bei...
