Phd (W/m/d)

vor 2 Monaten

Hannover, Deutschland Universitätsmedizin Göttingen Vollzeit

The institue of cell biochemistry is looking for a

**PhD (w/m/d)**:

- Spezialisierung: PhD positions on mitochondrial gene expression and protein transport are currently available in the group of Peter Rehling.
- Befristung: 3 years
- Arbeitszeit: 25,025 hours/week
- Entgelt: salary according to TV-L
- Anzeige veröffentlicht am 20.07.2023
- Stelle zu besetzen ab 20.07.2023
- Bewerbungsschluss: 20.08.2023

Our reserach aims at understanding the dunction and biogenesis of mitochondria. Mitochondria play important and diverse roles in eukaryotic cells, and their dysfunction is linked to servere disease in humans. We are specially interested in the molecular mechanisms underlying mitochondrial gene expression, in how nuclear-encoded proteins are imported into mitochondria and how the molecular defects underlying mitochondrial disorders. In our projects, we combine molecular biology with biochemical, and cell biological approaches. For recent publications: Dennerlein S, et all (2021) Defining the interactome of the mitochondrial ribosome identifies SMIM4 and TMEM223 as respiratory chain assembly factors. eLife 10 e68213; Gomkale R (2021) Mapping protein interactions in the active TOM-TIM23 interface. Nature Comm. 12. 5715; Yousefi R (2021) Monitoring mitochondiral translation in living cells. EMBO Rep. 22(4):e51635 Cruz Zaraogoza LD (2021) An in vitro system to silence mitochondrial gene expression. CELL 184:5824-2837

We are seeking to fill pHD positions in our international research group located in the environment of the Göttingen research campus with a tight network of international cooperation. We offer an exciting and highly stimulating environment.

Activities and responsibilities:
We are seeking doctoral students with interested in working on molecular aspects of mitochondrial protein biogenesis. The project aims to identify the molecular mechanisms by which translation in human mitochondria is regulated in order to provide an optimal supply of proteins to cope with cellular demands. Moreover, we investigate the mechanisms by which proteins are transport into mitochondria. Special emphasis is given to the implication of regulatory process for the pathology of mitochondrial disorders. Our work utilizes a wide range of molecular biological, biochemical and genetic approaches and aims to develop new model systems for functional analyses.

Your responsibilities:

- combine cutting-edge cell biology, protein
- and RNA biochemistry as well as other methods to dissect mitochondrial molecular biology from the molecular to the organellar scale
- drive your own research project in a collaborative team with close mentoring and supervision
- present & communicate research results at national and international scientific meetings
- gain experience in mentoring and teaching of students

Our offer:

- high-impact research field with biomedical relevance
- international and diverse research group with a strong team spirit and an open-minded, collaborative and respectful working atmosphere
- access to state-of-the-art infrastructure & hands-on training in latest methods in molecular biology and biochemical methods.
- structured cross-institutional graduate program that offers numerous mentoring and career support opportunities

Qualification profile:

- applicants should hold a M.Sc. or equivalent degree in the life sciences or a related discipline
- previous experience in molecular biology, protein
- or RNA biochemistry is advantageous, but not essential
- fluent English language skills (written and spoken) are required

Unser Ziel als Universitätsmedizin Göttingen ist die berufliche Gleichstellung aller Geschlechter. Wir streben in Bereichen, in denen eine Unterrepräsentation vorliegt, eine Angleichung des Geschlechterverhältnisses an. Der beruflichen Teilhabe von schwerbehinderten Menschen sieht sich die Universitätsmedizin Göttingen in besonderer Weise verpflichtet und begrüßt deshalb Bewerbungen schwerbehinderter Menschen. Bei gleicher Eignung werden Bewerbungen schwerbehinderter Personen nach Maßgabe der einschlägigen Vorschriften bevorzugt berücksichtigt. Wir bitten Sie, eine Behinderung/Gleichstellung zur Wahrung Ihrer Interessen bereits im Bewerbungsschreiben anzugeben.

Ihre Bewerbung richten Sie bitte bis zum 20.08.2023 an:
Universitätsmedizin Göttingen

Department of Cellular Biochemistry
- Prof. Dr. Peter Rehling
- Humboldtallee 23

37073 Göttingen
- Tel.: 0551/39-65947

Bitte reichen Sie Ihre Bewerbungsunterlagen ausschließlich per E-Mail im PDF-Format in einer Datei ein.

Wir bitten Sie um Verständnis, dass Fahrt
- und Bewerbungskosten nicht erstattet werden können.

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