Erc-funded Phd and Postdoc Positions in Comparative

Vor 3 Tagen

Frankfurt am Main, Deutschland Springer Nature Vollzeit

**ERC-funded PhD and Postdoc Positions in Comparative Genomics**:

- Employer- Senckenberg Society for Nature Research- Location- Frankfurt am Main, Hessen (DE)- Salary- acc. to collective agreement of the State of Hesse (TV-H), pay grade E13 (PostDoc 100%, PhD 75%)- Closing date- 2 Jul 2024- Discipline
Biomedicine, Earth Science, Environmental Science, Life Science
Job Type
Bioinformatician, PhD Position, Postdoctoral, Researcher
Employment - Hours
Full time
Duration
Fixed term
Qualification
Masters
Sector
Academia- You need to sign in or create an account to a job.

**ERC-funded PhD and Postdoc Positions in Comparative Genomics**
(full time / part-time options available)
The Hiller Lab at the LOEWE Center for Translational Biodiversity Genomics (TBG) in Frankfurt, Germany has two openings for a PhD student and/or a Postdoc to work on the BATPROTECT project to investigate the genomic basis of long healthspans, disease resistance, and viral tolerance in bats.

**BATPROTECT**
is a 6-year funded ERC synergy grant project that will use bats as natural models of healthy aging and disease tolerance to elucidate the molecular mechanisms behind bats’ exceptional longevity and resistance to viral and age-related diseases. BATPROTECT brings together a team of global leaders in bat biology and ageing (Emma Teeling, Dublin), bat immunology and virology (Linfa Wang, Singapore), evolution and genomics (Michael Hiller, Frankfurt), and ageing model organisms (Bjoern Schumacher, Cologne) that will jointly investigate aging and immune responses in bats from the wild and captive colonies, discover genes with evolutionary importance for longevity and disease resistance, and functionally validate longevity and immune regulators in stem and differentiated cells of bats and model organisms, with the ultimate goal to uncover new directions to improve human healthspan and disease outcome.

**The Project**
The overall goal is to uncover the genomic basis of exceptional healthspans and disease tolerance in bats, understand the evolution of these traits, and identify key molecular targets for functional validation. To this end, we will assemble ~150 new reference-quality bat genomes using HiFi and HiC sequencing to better cover the diversity of bats, generate comparative transcriptomic datasets, and analyze these data using our established methods repertoire (TOGA and others). Work includes phylogenomics, performing comparative screens to identify key adaptations in coding and non-coding (miRNA) genes as well as differences in gene expression patterns across the bat phylogeny, associating genomic changes with longevity and viral reservoir status traits, identifying novel bat genes, and investigating endogenized viral elements. The exact project will be defined based on the interests of the applicants.
The PhD student and postdoc will work closely with other members of the BATPROTECT team, the Hiller lab, and other Bat1K collaborators. We also offer exchanges with the other BATPROTECT labs as well as yearly retreats with all project members.

**Your profile**
- Master or PhD degree in bioinformatics/computational biology, genomics or a related area
- Solid programming skills in a Linux environment, experience with shell scripts and Unix tools
- Strong interest in comparative genomics, experience in comparative genomics is an advantage
- English in written and oral form

**Our lab**

**Senckenberg and TBG provide**
- Flexible working hours - opportunities for mobile working - leave of absence due to family reasons (certified by “auditberufundfamilie”) - parent-child office - annual special payment - company pension scheme - Senckenberg badge for free entry in museums in Frankfurt. - leave of 30 days/year
- Frankfurt is a vibrant and highly international city at the heart of Europe that combines a skyscraper skyline with ample parks and green areas. The Economist 2022 index ranked Frankfurt among the top 10 most livable cities worldwide.

Place of employment: Frankfurt am Main
Working hours: Full-time (40 hours/week) / part-time options are available
Type of contract: funding is available for 6 years
Postdoc: initially limited to 2 years / PhD: initially limited to 3 years
Start date: flexible, ideally summer of 2024
Salary and benefits: according to the collective agreement of the State of Hesse (TV-H), pay grade E13 (PostDoc 100%, PhD: 75%)- a CV with publication list and contact information for at least two references
- a summary of previous research experience (max 1 page)
- and copies of certificates, transcripts and grades

Senckenberg Gesellschaft für Naturforschung
Senckenberganlage 25
60325 Frankfurt a.M.

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