Student (F/m/d) for a Master Thesis in The Core

vor 6 Monaten


Duesseldorf, Deutschland IUF - Leibniz-Institut für umweltmedizinische Forschung GmbH Vollzeit

The working group “Genome Engineering and Model Development (GEMD)” led by Dr. Andrea Rossi is looking for a student (f/m/d) for a master thesis with the title: Characterization of brain organoids as a model for Cockayne Syndrome.

**The project**:
Cockayne Syndrome (CS) is a rare inherited premature aging disorder which is caused by mutations in the CSA or CSB gene. In CS patients, the brain, which is one of the most severely affected organs, displays a complex pattern of developmental impairment and degenerative features particularly contributing to the fatal progress of the disease. However, the molecular mechanisms driving these changes still remain largely unknown which can in part be explained by the lack of appropriate models.

To overcome this problem, we generated brain organoids from induced pluripotent stem cells (iPSCs) either carrying disease-causing mutations in the CSB gene or the normal variant as a control. These brain organoids, which resemble the structure of the human brain and which can be cultivated for up to several months _in vitro_, represent an ideal model to study brain development under disease and normal conditions.

The aim of this project is to generate and characterize normal and CS brain organoids using various molecular biological, biochemical and histological methods (Real Time PCR, Western blot, ELISA ) to identify molecular targets and pathways involved in the pathology of CS and get a better understanding of the molecular mechanisms driving the disease.

**Your profile**:
**We offer**:
The opportunity to learn and work with state-of-the-art techniques to study brain development in a currently uncurable disease and to identify novel pathomechanisms which may be of relevance for generating new therapeutic strategies for CS. Join an interdisciplinary international team with a pleasant and collegial working atmosphere for committing the next step in your scientific career.

**Start**: As soon as possible

Dr. Andrea Rossi
IUF - Leibniz-Institut für umweltmedizinische Forschung
c/o Personalstelle
Auf’m Hennekamp 50
40225 Düsseldorf

Application documents submitted by post are not returned. Documents for applicants not considered are destroyed appropriately once the procedure is complete.



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