Doctoral Project Opportunity

vor 3 Wochen


Duesseldorf, Deutschland Forschungszentrum Jülich Vollzeit

**Your Job**:
We are looking for a doctoral researcher who will:

- generate cerebral organoids from human induced pluripotent stem cells (iPSC), incorporate microglia consecutively
- grow organoids on (i) soft silicone cushions or (ii) in agarose within a tissue stretching/compression system, respectively, to compress them within defined parameters, simulating TBI in vitro
- assess cultures for key functions including cell survival, cell proliferation, neuronal functionality (Ca2+ imaging), and TBI biomarkers
- compare organoid cultures with neuronal-astroglial co-cultures grown on microstructured elastomeric substrates allowing the development of functional neuronal network clusters and single cell read-outs
- assess the effects of a therapeutic pharmacological intervention in this TBI model in vitro using the read-outs listed above

Practical work will take place at Forschungszentrum Jülich and University Hospital of Cologne (mobility between those institutions is required).

**Your Profile**:

- Expertise in cell culture and light microscopy
- Experience in interdisciplinary work
- Knowledge in image processing and statistical data evaluation
- Medical, mechanobiological, or biological background required
- Strong motivation for pursuing a doctoral degree within four years in an ambitious but rewarding interdisciplinary project related to neuroscience and mechanobiology
- Willingness to commute between Jülich and Cologne

**Our Offer**:
We offer ideal conditions for you to work on a doctoral project at the leading edge of science, including:

- Excellent scientific and technical infrastructure
- Continuous supervision by a team of experts
- A vibrant international work environment on an attractive research campus, ideally situated between the cities of Cologne, Düsseldorf, and Aachen
- Extensive company health management, as well as social security and health insurance
- 30 days of annual leave and provision for days off between public holidays and weekends (e.g. between Christmas and New Year)
- Targeted services for international employees, e.g. through our International Advisory Service

The PhD position is fixed for a term of 4 years. Pay in line with the Collective Agreement for the Public Service (TvÖD-Bund).


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