Postdoctoral Fellowship

Research
- EMBL Heidelberg

Your role

You will be the lead-computational scientist for the overall SYMPHONY project, performing discovery-oriented research on the large datasets acquired and generated by the consortium, developing new methodology, and advising partners on approaches and tools. To support these activities, you will also engage in critical method assessment and benchmarking, in collaborative data management, including visualization and QA/QC, and in integrative analysis of consortium data with other, extant data. The primary data type will be barcoded sequencing libraries to determine fitness or viability phenotypes of the many CRISPR-induced mutant genotypes under study. An exciting aspect of the project is the “Car-Pool-Seq” system, which can co-disrupt gene pairs and capture the functional consequences by measuring gene expression responses at single-cell resolution. The systematic perturbation of thousands of genes across dozens of lung cancer models will enable understanding of how genes interact to sustain cancer cell viability and provide novel starting points for therapy development.

**Closing date**: 31 March 2023

Contract duration: 3 years

Grading: NA

Reference number: HD02370

You have

You might also have

a background in biological data science, and/or experience with R package development, interactive visualization, reproducible research and open science technologies.

Why join us

EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organization with a collegial and family-friendly working environment. The remuneration package comprises a competitive salary, a comprehensive pension scheme, medical, educational and other social benefits, as well as financial support for relocation, including your family and the availability of an excellent child care facility on campus. EMBL has a large, thriving community of computational biologists, working in close collaboration with experimental scientists and with strong links to other local and international scientists and institutions.

What else you need to know

We are Europe’s flagship research laboratory for the life sciences - an intergovernmental organization doing scientific research in disciplines including molecular biology, physics, chemistry and computer science. We are an international, innovative and interdisciplinary institution with more than 1600 employees from more than 60 nations, operating across six sites in Heidelberg, Barcelona, Cambridge, Grenoble, Hamburg, and Rome. Our mission is to offer vital services in training scientists, students and visitors at all levels; to develop new instruments and methods in the life sciences and actively engage in technology transfer activities, and to integrate European life science research. Please note that appointments on fixed term contracts can be renewed, depending on circumstances at the time of the review.