Phd Student
Vor 3 Tagen
**PhD student (f/m/x)**:
Code: 1310/2024/4
The group of Dr. Daniele Bano studies metabolic pathways contributing to neurodegenerative diseases. One line of research investigates molecular mechanisms that promote longevity and healthspan (Piazzesi A. et al, 2022; Jackson J. et al, 2022; Gioran A. et al, 2019; Piazzesi A. et al, 2016; Gioran A. et al, 2014). In the context of primary mitochondrial diseases, the laboratory aims to identify compensatory pathways that can ameliorate metabolic defects linked to inherited genetic lesions of the mitochondrial oxidative phosphorylation system (unpublished data; Wischhof L. et al, 2022; Bertan F. et al, 2021; Wischhof L. et al, 2018; Troulinaki K. et al, 2018; Meyer K. et al, 2015).
**Your tasks**:
The team is searching for a highly motivated and science-driven PhD student to investigate the impact of proteasome inhibition on mitochondrial homeostasis. Using the nematode Caenorhabditis elegans, the newly recruited team member will model pathogenic processes associated with proteasome variants previously identified in patients with rare forms of neurodevelopmental proteasomopathies. Experimental evidence in invertebrate will be further corroborated in patient-derived iPSC models, from which neuronal and glial cultures will be generated. The project is part of a newly established collaboration with the teams of Prof. Alexander Bartelt (LMU, München) and Prof. Elke Krüger (Universität Greifswald).
**Requirements**:
**We offer**:
- An interesting and challenging task in a research center that works on the future topics of health research
- An international environment characterized by a strong focus on science and research
- Targeted personnel development
- A position, initially temporary limited to 2 years
- Employment, payment and social benefits are consistent with those at other research institutes
**Site**: Bonn
**Contact details**:
Dr. Daniele Bano
**Working hours**:
full-time
**Contract length**:
2 years, extension possible
**Payment, social benefits**:
consistent with those at other research institutes
**Application deadline**:
June 30th, 2024
- You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE. Our Institute is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply._
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