Lab Head/junior Group Lead

vor 4 Wochen

Augsburg, Deutschland Universitätsklinikum Augsburg Vollzeit

The **Children’s Hospital Augsburg (Swabian Children’s Cancer Center)** and the **University of Augsburg** (Lead: Prof. Dr. Pascal Johann) are looking for a Lab head/junior group lead in experimental and computational pediatric brain tumor research. Position limited to two years.

Recently, we have performed integrative, large-scale multi-omic characterizations of pediatric rhabdoid tumors (Johann et al. Cancer Cell 2016; Erkek, Johann et al, Cancer Cell 2019, Fincke et al. 2022, Cancers) and are now aiming to expand these techniques to other SMARCB1-deficient tumors. Furthermore, to facilitate the translation of the results back to the clinic, we will perform high-throughput drug screens which complement the multi-omics characterization of the tumors. To handle both the experimental and the computational part of this project, we are looking for a highly-motivated PhD student, who is able to work at the interface of molecular biology, epigenetics and computational biology.

As clinic of the University Hospital Augsburg (UKA), we are part of a rapidly growing academic center. The UKA is a large-scale care provider with 1699 patient beds in 22 clinics and approximately 2800 employees. Scientifically, the hospital is member of the NCT-WERA cooperation and thus one location of the NCT (national center for tumor diseases).

Job describtion
We are looking for a motivated postdoc with a background in functional epigenetic work and computational biology and an interest in both wet and dry lab work. Our aim is to decipher the epigenetic landscape of various neoplasias that are characterized by the loss of the tumor-suppressive SMARCB1 protein, including rhabdoid tumors and epithelioid sarcomas.

The successful applicant will be responsible for setting up and further developing a junior research group dedicated to methods of epigenetic characterization in pediatric brain tumors and endocrine tumors. The training of PhD and MD students is an integral part of the tasks.

**Requirements**:

- PhD in biology, cancer biology, genetics, bioinformatics or a related field (with demonstrated experience in both bioinformatics and experimental work)
- Previous experience in the functional analysis of epigenetic complexes such as the SWI/SNF and/or PRC1/2 complexes is helpful and highly desired
- Experience with state of the art methods for epigenetic characterization (e.g. ChIP Sequencing)
- Ability to collaborate and communicate within interdisciplinary teams (in German and English)

We offer
- Joint appointment at the University of Augsburg (Prof. P.Johann) and integration into both a clinical / experimental and a computational working group.
- The opportunity to learn a wide variety of experimental and computational methods
- Support in generating an own, academic profile
- The grouping takes place up to EG 14 TV-L taking into account your qualifications and personal requirements including the social benefits customary in the public service (company pension, annual special payment)

Further information

Do you have any questions about the advertised position?

Application documents

We look forward to you

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